干扰素诱导蛋白10在呼吸道病原微生物感染诊断和疾病监测中的研究进展

Research progresses of interferon-induced protein 10 in the diagnosis and monitor of respiratory infectious diseases

干扰素诱导蛋白10(interferon inducible protein 10,IP-10)是Cys-X-Cys(CXC)趋化因子家族成员之一,其受体为CXCR3。IP-10具有多种生物学功能,如趋化T细胞、单核细胞、NK细胞在内的CXCR3+细胞到炎症部位发挥抗炎或促炎作用。研究发现,IP-10与呼吸道病原微生物感染及疾病进程相关,在结核感染的诊断,以及新型冠状病毒感染和高致病性禽流感等急性严重呼吸道感染性疾病进程的监测中发挥一定作用。因此,笔者主要围绕IP-10在各类呼吸道病原微生物感染的诊断及病程监测中的研究进展进行综述。

Interferon inducible protein 10(IP-10)is a member of the Cys-X-Cys(CXC)chemokine family,and its receptor is CXCR3.IP-10 has multiple biological functions,such as CXCR3+cells,including chemotactic T cells,monocytes and NK cells,play roles in the process of pro-inflammation or anti-inflammation.It was found that IP-10 is also associated with respiratory infectious diseases,it plays a certain role in the diagnosis of tuberculosis infection,as well as monitor the progress of acute and serious respiratory infectious diseases such as novel coronavirus infection and highly pathogenic avian influenza.Therefore,the progresses of IP-10 in the diagnosis and monitor of respiratory infectious diseases were reviewed in this article.