蒲地蓝消炎口服液联合羟氯喹治疗口腔扁平苔藓的临床研究

Clinical study on Pudilan Xiaoyan Oral Liquid combined with hydroxychloroquine in treatment of oral lichen planus

目的探讨蒲地蓝消炎口服液联合硫酸羟氯喹片治疗口腔扁平苔藓的效果。方法选择唐山市人民医院在2020年11月—2023年6月收治82例口腔扁平苔藓患者,将所有患者根据随机数字表法分为对照组(41例)和治疗组(41例)。对照组口服硫酸羟氯喹片,1片/次,2次/d。治疗组在对照组基础上口服蒲地蓝消炎口服液,10 mL/次,3次/d。两组持续治疗4周。比较两组的临床疗效、体征积分、疼痛程度、口腔黏膜病损面积和血清指标。结果治疗后,治疗组的总有效率(92.68%)明显高于对照组(75.61%),差异有统计学意义(P<0.05)。治疗后,两组的体征积分、数字疼痛强度量表(NRS)评分、病损面积均明显低于治疗前(P<0.05),治疗组的体征积分、NRS评分、病损面积均低于对照组(P<0.05)。治疗后,两组的血清白细胞介素-17(IL-17)、神经生长因子(NGF)、白细胞介素-12(IL-12)水平均低于治疗前(P<0.05),治疗组血清IL-17、NGF、IL-12水平均低于对照组(P<0.05)。结论蒲地蓝消炎口服液联合硫酸羟氯喹片可提高口腔扁平苔藓的治疗效果,减轻症状和体征,缩小病损面积,降低炎症反应。

Objective To investigate the effect of Pudilan Xiaoyan Oral Liquid combined with Hydroxychloroquine Sulfate Tablets in treatment of oral lichen planus.Methods Patients(82 cases)with oral lichen planus in Tangshan People’s Hospital from November 2020 to June 2023 were divided into control and treatment groups according to the random number table method,and each group had 41 cases.Patients in the control group were po administered with Hydroxychloroquine Sulfate Tablets,1 tablets/time,twice daily.Patients in the treatment group were po administered with Pudilan Xiaoyan Oral Liquid on the basis of the control group,10 mL/time,three times daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical efficacies,the physical signs score,NRS scores,lesion area,and serum indexes in two groups were compared.Results After treatment,the total effective rate of the treatment group(92.68%)was significantly higher than that of the control group(75.61%),and the difference was statistically significant(P<0.05).After treatment,the physical signs score,NRS score,and lesion area were significantly lower than those before treatment(P<0.05),and the physical signs score,NRS score,and lesion area of the treatment group were lower than those of the control group(P<0.05).After treatment,the serum levels of IL-17,NGF,and IL-12 in two groups were lower than those before treatment(P<0.05),and the serum levels of IL-17,NGF,and IL-12 in the treatment group were lower than those in the control group(P<0.05).Conclusion Pudilan Xiaoyan Oral Liquid combined with Hydroxychloroquine Sulfate Tablets can improve the therapeutic effect of oral lichen planus,reduce symptoms and signs,reduce the area of lesion,and reduce inflammation.