银花泌炎灵片联合诺氟沙星治疗Ⅲ型前列腺炎的临床研究

Clinical study on Yinhua Miyanling Tablets combined with norfloxacin in treatment of type Ⅲ prostatitis

目的探讨银花泌炎灵片联合诺氟沙星胶囊治疗Ⅲ型前列腺炎的临床效果。方法选取2021年1月—2022年12月上海市浦东新区浦南医院收治的83例Ⅲ型前列腺炎患者作为研究对象,采用随机数字表法将患者分为对照组(41例)和治疗组(42例)。对照组口服诺氟沙星胶囊,0.4 g/次,2次/d。治疗组在对照组基础上口服银花泌炎灵片,4片/次,4次/d。两组连续治疗8周。比较两组的临床疗效、病情程度、尿流动力学指标和血清炎症因子。结果治疗后,治疗组的总有效率(97.62%)明显高于对照组(80.49%),差异有统计学意义(P<0.05)。治疗后,两组美国国立卫生研究院慢性前列腺炎症状(NIH-CPSI)评分较治疗前明显降低(P<0.05),且治疗组NIH-CPSI评分低于对照组(P<0.05)。治疗后,两组患者最大尿流率均升高,残余尿量均下降(P<0.05),且治疗组最大尿流率高于对照组,残余尿量组低于对照组(P<0.05)。治疗后,两组血清白细胞介素-8(IL-8)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)水平较治疗前下降(P<0.05),且治疗组血清IL-8、IL-10、TNF-α水平较对照组更低(P<0.05)。结论银花泌炎灵片联合诺氟沙星胶囊对Ⅲ型前列腺炎的临床疗效良好,可有效缓解病情,改善尿流动力学,降低炎症反应程度。

Objective To investigate the clinical effect of Yinhua Miyanling Tablets combined with Norfloxacin Capsules in treatment of type Ⅲ prostatitis.Methods Patients(83 cases)with type Ⅲ prostatitis in Shanghai Punan Hospital of Pudong New Area from January 2021 to December 2022 were divided into the control group(41 cases)and the treatment group(42 cases)according to random number tablet method.Patients in the control group were po administered with Norfloxacin Capsules,0.4 g/time,twice daily.Patients in the treatment group were po administered with Yinhua Miyanling Tablets on the basis of the control group,4 tablets/time,four times daily.Patients in two groups were treated for 8 weeks.The clinical efficacy,condition,urodynamic indexes,and serum inflammatory factors in two groups were compared.Results After treatment,the total effective rate of the treatment group(97.62%)was significantly higher than 80.49% of the control group,and the difference was statistically significant(P<0.05).After treatment,NIHCPSI score of two groups was significantly lower than that before treatment(P<0.05),and NIH-CPSI score of the treatment group was significantly lower than that of the control group(P<0.05).After treatment,the maximum urine flow rate increased in two groups,but the residual urine volume in two groups decreased(P<0.05).And the maximum urine flow rate in the treatment group was higher than that in the control group,but the residual urine volume in the treatment group was lower than that in the control group(P<0.05).After treatment,the serum levels of IL-8,IL-10,and TNF-α in two groups were significantly decreased compared with that before treatment(P<0.05),and the serum levels of IL-8,IL-10,and TNF-α in the treatment group were lower than those in the control group(P<0.05).Conclusion Yinhua Miyanling Tablets combined with Norfloxacin Capsules has good efficacy in treatment of type Ⅲ prostatitis,which can effectively alleviate the condition,improve urodynamics,and reduce the degree of inflammatory response.