基于Wnt/β-catenin信号通路干预糖尿病足创面愈合的中药研究进展

Intervention in Wound Healing of Diabetic Foot with Traditional Chinese Medicine via Wnt/β-Catenin Signaling Pathway

糖尿病足(DF)是糖尿病严重的足部并发症。糖尿病患者因神经及血管病变、合并细菌感染等导致破损创面易发溃疡,久治不愈。DF创面愈合较正常伤口表现为持续的炎症、血管生成受阻、组织增殖及重塑异常。Wnt/β-catenin信号通路是调控器官发育和再生、维持干细胞多能性的重要通路,与DF创面愈合密切相关。综述近年来基于Wnt/β-catenin通路干预DF创面愈合的中药研究进展,以期为DF的新药研发与临床治疗提供参考。

Diabetic foot(DF)is a serious foot complication of diabetes.Due to nervous and vascular lesions,together with bacterial infection,etc.,the wounds of diabetic patients are prone to ulcers and are difficult to cure.DF wound healing showed persistent inflammation,blocked angiogenesis,abnormal tissue proliferation and remodeling compared with normal wounds.Wnt/β-catenin signaling pathway is an important way to regulate organ development,regeneration and maintain stem cell pluripotency,and is closely related to DF wound healing.This paper reviews the research progress of traditional Chinese medicine based on Wnt/β-catenin pathway in the intervention of DF wound healing in recent years,aiming to provide reference for the development of new drugs and clinical treatment of DF.