转化生长因子-β1、胰岛素样生长因子-1在食管癌组织中的表达及与患者临床特征和预后的关系

Expression of transforming growth factor-β1 and insulin-like growth factor-1 in esophageal cancer tissue and their relationship with clinical characteristics and prognosis

目的探讨转化生长因子-β1(TGF-β1)、胰岛素样生长因子-1(IGF-1)在食管癌组织中的表达及与患者临床特征和预后的关系。方法取81例食管癌患者的食管癌组织及相应癌旁组织,免疫组化法检测TGF-β1、IGF-1的表达情况,比较不同浸润深度及淋巴结转移情况食管癌患者食管癌组织中TGF-β1、IGF-1的表达情况。食管癌患者预后不良的影响因素采用多因素Logistic回归模型分析。结果食管癌组织TGF-β1、IGF-1的阳性表达率均明显高于癌旁组织,差异均有统计学意义(P﹤0.01)。浸润深度为T_(3~4)、发生淋巴结转移食管癌患者食管癌组织中TGF-β1、IGF-1的阳性表达率分别明显高于浸润深度为T_(1~2)、未发生淋巴结转移患者,差异均有统计学意义(P﹤0.01)。多因素Logistic回归分析结果显示,TNM分期为Ⅲ~Ⅳ期、浸润深度为T_(3~4)、发生淋巴结转移、TGF-β1阳性表达、IGF-1阳性表达均是食管癌患者预后不良的独立危险因素(P﹤0.05)。结论食管癌组织中TGF-β1、IGF-1阳性表达率较高,其表达与浸润深度及淋巴结转移情况密切相关,且是食管癌患者预后不良的独立危险因素。

Objective To investigate the expression of transforming growth factor-β1(TGF-β1)and insulin-like growth factor-1(IGF-1)in esophageal cancer tissue and their relationship with clinical characteristics and prognosis.Method The esophageal cancer tissues and corresponding adjacent tissues were collected from 81 patients with esophageal cancer,the expression of TGF-β1 and IGF-1 were detected by immunohistochemistry,the expression of TGF-β1 and IGF-1 in esophageal cancer tissues of esophageal cancer patients with different infiltration depth and lymph node metastasis were compared.The influencing factors of poor prognosis in esophageal cancer patients were analyzed by multivariate Logistic regression model analysis.Result The positive expression rates of TGF-β1 and IGF-1 in esophageal cancer tissues were significantly higher than those in adjacent tissues,the differences were statistically significant(P<0.01).The positive expression rates of TGF-β1 and IGF-1 in esophageal cancer tissues of patients with infiltration depth T_(3~4) and lymph node metastasis were significantly higher than those of patients with infiltration depth T_(1~2) and no lymph node metastasis(P<0.01).Multivariate Logistic regression analysis showed that TNM stage III-IV,infiltration depth T_(3~4),lymph node metastasis,TGF-β1 positive expression,and IGF-1 positive expression were independent risk factors for poor prognosis in esophageal cancer patients(P<0.05).Conclusion The positive expression rates of TGF-β1 and IGF-1 are high in esophageal cancer tissues,and their expression are closely related to the infiltration depth and lymph node metastasis,and are independent risk factors for poor prognosis in esophageal cancer patients.