3,5-二叔丁基-4羟基苯基丙酸甲酯合成技术优化研究

Improvement of the Synthesis of Methyl-3-(3,5-Di-Tert-Butyl-4-Hydroxyphenyl)-Propionate

研究了2,6-二叔丁基苯酚和丙烯酸甲酯的Michael加成反应机理。考察了不同催化剂配比对该反应体系的影响,确定较优的催化剂配比为KOH与NaOH物质的量比为4,n(M^(+))/n(酚)=3%。在该催化剂配比下,对原料配比、滴加速率、反应压力、反应温度、反应时间等工艺参数进行了系统的研究,得出3,5-二叔丁基-4羟基苯基丙酸甲酯的最优合成工艺参数。该结果可用于指导实际生产中的操作优化。

The reaction principle of the synthesis of methyl-3-(3,5-di-tert-butyl-4-hydroxyphenyl)-propionate by 2,6-di-tert-butyl-phenol and methyl acrylics(MA)is studied.Different catalysts'effect on the synthesis is analyzed,the optimized catalyst formulation is n(KOH)/n(NaOH)=4 and n(M^(+))/n(phenol)=3%.Then a systematic study is conducted on various process parameters such as the raw material ratio,MA dosing speed,reaction pressure,reaction temperature,reaction holding time and so on.The optimum conditions are obtained,which may be useful for the industrial production optimization.