超分子水凝胶促进软骨再生的研究现状

Current researches on supramolecular hydrogel promoting cartilage regeneration

软骨由于缺乏血管、神经和淋巴,导致软骨的再生能力有限。传统的临床治疗方法均不能达到满意的疗效,而组织工程技术为软骨损伤的修复提供了新的方向。目前,软骨再生研究取得了巨大进步,但骨软骨界面和全层关节软骨缺损的修复仍然具有挑战性。超分子水凝胶是一类通过水凝胶剂的非共价相互作用形成的自组装网络结构,具有可调节机械强度、剪切变稀、较强的自愈合能力、良好的生物相容性和可注射性等优点,能够有效促进软骨再生。本文就超分子水凝胶的特点、合成机制、软骨再生情况和应用不足的研究现状进行了综述。

Cartilage has limited capacity of regeneration due to its lack of blood vessels,nerves,and lymph.Traditional clinical treatment methods cannot achieve satisfactory curative effect,but tissue engineering technology provides a new direction for the repair of cartilage damage.Currently,great progress has been made in cartilage regeneration,but the repair of osteochondral interface and full-thickness articular cartilage defects remains challenging.Supramolecular hydrogel is a kind of self-assembled network structures formed by non-covalent interactions of hydrogels,which has the advantages of adjustable mechanical strength,shear thinning,strong self-healing ability,good biocompatibility and injectability.It can effectively promote cartilage regeneration due to its properties.In this paper,the characteristics,synthesis mechanism,cartilage regeneration and insufficient application of supramolecular hydrogels were reviewed.