V(D)J重排酶RAG与转座子及转座子基因编辑工具的关系

The Relationship between V(D)J Recombinase RAG and Transposon and Transposon Gene Editing Tool

V(D)J重排是高等脊椎动物产生特异性抗体和受体的基础事件,是适应性免疫的特征,其关键酶重组激活基因(RAG)及V(D)J重排如何起源是免疫学中的一个基础问题。多种证据表明RAG和V(D)J重排可能起源于转座事件。本文就V(D)J重排酶RAG的功能,及其和原始RAG转座子的关系进行论述,同时思考RAG转座子和转座子基因编辑工具的联系,旨在为新型基因编辑工具研发和利用提供参考。

V(D)J rearrangement is a common event in the production of specific antibodies and receptors in vertebrates,it is an iconic characteristic of adaptive immunity.The origins of V(D)J rearrangement and its key recombinase recombination-activating gene(RAG)are fundamental issues in immunology.Multiple evidence has suggested that RAG and V(D)J rearrangements might originate from a transposition event.Here,we describe the functions of V(D)J recombinase RAG and discussed its relationship with the ancient RAG transposons,while also considering the connection between RAG transposons and transposon gene editing tools.Which may benefit to the research on the development and utilization of new gene editing tools.