2019—2022年重庆口岸妇科体检人群人乳头瘤病毒感染状况分析

Analysis of human papilloma virus infection among gynecological examination population at Chongqing port from 2019 to 2022

目的分析重庆口岸妇科检查人群人乳头瘤病毒(human papilloma virus,HPV)感染状况及基因亚型分布特征。方法采用PCR-反向点杂交法对2019年1月—2022年12月重庆国际旅行卫生保健中心妇科健康检查人员进行HPV检测分型,包括25种HPV亚型。结果2019—2022年接受HPV检测共有2123人,HPV感染215例,总感染率为10.13%,其中高危型HPV感染169例,感染率7.96%。由于存在多重感染,215例感染频次为282,20~<30岁年龄组感染频次最高,为143,感染率为6.74%。按感染频次计,前5位高危型HPV亚型依次是HPV52型(3.34%)、53型(1.08%)、16型(0.85%)、58型(0.80%)、51型(0.61%)。单一感染167例,感染率7.87%,其中低危型41例,感染率1.93%,高危型126例,感染率5.93%;单一感染前5位的高危型HPV亚型依次是52型(2.17%)、53型(0.71%,)、51型(0.47%)、16型(0.42%)、58型(0.38%)。多重感染48例,感染率2.26%(48/2123),其中双重感染34例,占感染人数的15.81%,感染率为1.60%;多重感染14例,占感染人数的6.51%,感染率为0.66%;多重感染中52型最多。不同年龄组HPV单一感染、双重感染及多重感染率差异有统计学意义(χ^(2)=19.5904,P=0.0120),其中20~<30岁感染最多见,其次为30~<40岁。结论重庆口岸妇科检查人群HPV感染以单一感染为主,感染率最高的是20~<30岁人群。

Objective To analyze the infection status of human papilloma virus(HPV)and the distribution of genotypes in gynecological examination population at Chongqing port.Methods PCR reverse dot hybridization method was used to test HPV and typing on gynecological health examination personnel at Chongqing International Travel Healthcare Center from January 2019 to December 2022,including 25 HPV subtypes.Results A total of 2123 women who received HPV genotypes detection,with 215 cases of HPV infection,the general infection rate was 10.13%.High-risk HPV infection was found in 169 cases,and the infection rate was 7.96%.Due to the presence of multiple infection,the actual infection frequency of HPV genotypes in 215 females was 282,the highest frequency of infection in 20-<30 age group was 143,and the infection rate was 6.74%.According to the actual frequency of infection,the top five high-risk HPV genotypes were HPV52(3.34%),53(1.08%),16(0.85%),58(0.80%)and 51(0.66%).167 female were HPV single infection,the infection rate was 7.87%.Among them,41 cases were low-risk infections,with infection rate of 1.93%,126 high-risk cases and infection rate of 5.93%.The top five high-risk HPV genotypes were 52(2.17%),53(0.71%),51(0.47%),16(0.42%)and 58(0.38%).48 cases were multiple infections with HPV,the infection rate was 2.26%(48/2123).Among them,34 cases were double infection,accounted for 15.81%of the cases,the infection rate was 1.60%,and 14 cases were multiple infection,accounted for 6.51%of the cases,and the infection rate was 0.66%.The main HPV genotypes for multiple infection was HPV52.The difference of infection rate of single infection,double infections,multiple infection in different age groups was statistically significant(χ^(2)=19.5904,P=0.0120),the highest HPV infection rate between 20-<30 years old,followed by 30-<40 years.Conclusion The mainly human papilloma virus infection of the gynecological health examiners at Chongqing port was single infection,the highest infection rate was in aged 20-<30 years old group.