乙肝病毒相关肝硬化并发急性上消化道出血的危险因素分析

Risk factors of acute upper gastrointestinal bleeding in hepatitis B virus-associated cirrhosis

[目的]研究乙肝病毒(HBV)相关肝硬化合并急性上消化道出血的危险因素,以期为临床诊治提供参考。[方法]将258例HBV相关肝硬化患者,按照是否合并急性上消化道出血分为研究组(142例,出血者)、对照组(116例,未出血者)。应用单因素分析HBV相关肝硬化合并急性上消化道出血的相关因素,再利用多因素Logistic分析对上述有差异的统计学资料进行进一步回归分析,最终探讨影响HBV相关肝硬化合并急性上消化道出血的危险因素。[结果]单因素分析显示,肝功能分级、凝血酶原时间、胃左静脉内径及血红蛋白为HBV相关肝硬化合并急性上消化道出血的危险因素,差异有统计学意义(P<0.05);多因素分析表明,肝功能分级、凝血酶原时间及胃左静脉内径为影响HBV相关肝硬化并急性上消化道出血的独立危险因素。[结论]HBV相关肝硬化合并急性上消化道出血的危险因素中肝功能分级、凝血酶原时间及胃左静脉内径为其独立危险因素。

[Objective]To study the risk factors of acute upper gastrointestinal bleeding in hepatitis B virus(HBV)-related cirrhosis,so as to provide reference for clinical diagnosis and treatment.[Methods]A total of 258patients with HBV-related cirrhosis admitted to our hospital from July 2016to July 2021were retrospectively analyzed.According if they were complicated with acute upper gastrointestinal bleeding,they were divided into bleeding group(study group,142cases)and non-bleeding group(control group,116 cases).Univariate analysis was used to analyze the risk factors of HBV-associated cirrhosis complicated with acute upper gastrointestinal bleeding,and multivariate Logistic analysis was used to further regression analysis of the above statistical data to finally explore the risk factors of HBV-associated cirrhosis complicated with acute upper gastrointestinal bleeding.[Results]Univariate analysis showed that liver function grade,prothrombin time,left gastric vein passage and hemoglobin were risk factors for HBV-related cirrhosis complicated with acute upper gastrointestinal bleeding,and the differences were statistically significant(P<0.05).Multivariate analysis,which included statistical differences in the above univariate analysis,showed that liver function grade,prothrombin time,and left gastric vein passage were independent risk factors for HBV-related cirrhosis with acute upper gastrointestinal bleeding.[Conclusion]Hepatic function grade,prothrombin time and left gastric vein meridian are independent risk factors for HBV-related cirrhosis complicated with acute upper gastrointestinal bleeding.