中药石膏药理作用研究进展与其清热物质基础探讨

Research progress in pharmacological effects of Gypsum Fibrosum and material basis for its heat-clearing effect

石膏作为经典清热药物在中医药临床上有着广泛应用,但其药效物质基础与作用机制仍然存在一定争议。因此,作者综述了近年来众多学者在矿物药石膏清热效果及机制方面的研究概况以及对石膏清热的物质基础进行探讨。分别从石膏的元素组成、药效物质基础及作用机制展开介绍与探讨,发现钙离子(Ca^(2+))可能通过降低体温调节中枢钠离子/钙离子(Na^(+)/Ca^(2+))水平,从而抑制体温调定点上移;微量元素可能是通过调节免疫系统,促进Ca^(2+)的吸收以及影响前列腺素E2(prostaglandin E2,PGE2)的合成,从而抑制体温升高。作者综述了石膏的药理作用研究进展并对其清热的物质基础进行探讨,旨在进一步了解石膏清热的作用机制,为石膏的临床应用以及进一步开发提供科学依据。

Gypsum Fibrosum,as a classic heat-clearing medicine,is widely used in the clinical practice of traditional Chinese medicine(TCM).However,debates exist about the material basis and mechanism of its efficacy.Therefore,this paper reviewed the recent research progress in the heat-clearing effect and mechanism of Gypsum Fibrosum and discussed the material basis for the heat-clearing effect of this medicine.Ca~(2+) may inhibit the upward movement of temperature set point by regulating the Na~+/Ca~(2+) level in the heat-regulating center.Moreover,trace elements may inhibit the rise of body temperature by regulating the immune system,promoting the absorption of Ca~(2+),and affecting the synthesis of prostaglandin E2(PGE2).This review aims to enrich the knowledge about the mechanism of Gypsum Fibrosum in clearing heat and provides a scientific basis for the clinical application and further development of Gypsum Fibrosum.