NLRP3炎症小体在心力衰竭中的作用及中医药干预的研究进展

Role of NLRP3 inflammasome in heart failure and traditional Chinese medicine intervention:a review

心力衰竭存在高发病率、高病死率的特征,寻求针对心力衰竭的有效治疗策略并进一步提升临床疗效一直是重要的研究方向。炎症失衡已被证明是心力衰竭的重要病理环节之一,与心功能障碍、心肌纤维化等不良事件呈正相关。近些年研究证实NOD样受体热蛋白结构域相关蛋白3(NOD-like receptor thermal protein domain-associated protein 3,NLRP3)炎症小体激活在不同因素诱导心力衰竭的炎症失衡环节中具有共性调控机制,并且部分中药及其有效成分能够显著抑制NLRP3炎症小体激活而改善心力衰竭。该文首先概述了NLRP3炎症小体的基本情况,然后总结了NLRP3炎症小体在不同因素诱导心力衰竭中的调控机制,最后介绍了近年来抑制NLRP3炎症小体而改善心力衰竭的中药及有效成分的研究进展,以期为中西医结合防治心力衰竭的创新药物研究提供参考。

Heart failure is characterized by high incidence and mortality rates,and the search for effective treatment strategies for heart failure and the improvement of clinical outcomes have always been important research directions.Imbalanced inflammation has been proven to be one of the critical pathological factors in heart failure,positively correlated with adverse events such as impaired cardiac function and myocardial fibrosis.In recent years,studies have confirmed that the activation of the NOD-like receptor thermal protein domain-associated protein 3(NLRP3) inflammasome plays a common regulatory role in the inflammation imbalance induced by various factors in heart failure.Moreover,certain traditional Chinese medicine(TCM) and active components can significantly inhibit the activation of the NLRP3 inflammasome,thereby improving heart failure.This article first overviewed the basic information about the NLRP3 inflammasome,summarized the regulatory mechanisms of the NLRP3 inflammasome in heart failure induced by various factors,introduced recent research progress on TCM and active components that inhibited the NLRP3 inflammasome to improve heart failure,aiming to provide references for innovative drug research in the field of integrated Chinese and western medicine for the prevention and treatment of heart failure.