西罗莫司在生殖领域的研究进展

Research Progress of Sirolimus in the Field of Reproduction

西罗莫司作为常用的免疫抑制剂,现广泛用于预防器官移植受者发生免疫排斥反应。随着医学研究的不断发展,已证明西罗莫司在女性生殖过程中具有免疫调节作用。西罗莫司通过抑制哺乳动物雷帕霉素靶蛋白发挥免疫调节功能,可能会改善合并反复种植失败、复发性流产、子宫内膜异位症、慢性子宫内膜炎及多囊卵巢综合征等生殖系统疾病患者的生殖免疫状态。西罗莫司还可预防辅助生殖治疗过程中卵巢过度刺激综合征的发生,提高母胎界面免疫状态异常患者的胚胎种植率和临床妊娠率,实现更好的妊娠结局。综述西罗莫司在女性生殖相关疾病中的作用机制、研究现状及安全性。

Nowadays,sirolimus as a popular immunosuppressant has been frequently used to shield the organ transplant recipients from immunological rejection.The immunomodulatory effects of sirolimus in the female reproductive process have been demonstrated by ongoing medical study.By blocking the immune-regulating action of mammalian target of rapamycin,sirolimus may help those patients with recurrent implantation failure,recurrent spontaneous abortion,endometriosis,chronic endometritis,polycystic ovary syndrome,and other illnesses of the reproductive system.Additionally,sirolimus can enhance the rates of embryo implantation and clinical pregnancy in individuals with aberrant immunological statuses at the mother-fetal interface,reduce ovarian hyperstimulation syndrome during assisted reproductive treatment,and improve the pregnancy outcomes.A review was conducted on the mode of action,research status and safety of sirolimus in female reproductive disorders.