青春发动时相影响因素研究进展

Research advance in the influencing factors of pubertal timing

青春期是性成熟和机体生长发育的关键时期,青春发动期各事件初现的时间称为青春发动时相。近年来研究表明,青春发动时相发生异常变化主要是受到遗传、环境、营养、种族、生命早期因素等多种因素影响。本综述主要阐述目前青春发动时相影响因素和相关疾病的研究进展,以期为临床相关疾病的预防提供理论依据。

Adolescence is a critical period for sexual maturation and physical growth,and the time of the first appearance of events during puberty initiation is called puberty timing.Recent studies have shown that abnormal changes in the pubertal timing are mainly influenced by genetic,environmental,nutritional,ethnic,and early-life factors.This review focuses on the current research progress of factors influencing puberty onset phase and related disease,in order to provide theoretical basis for prevention of clinical related diseases.