lncRNA-TUG1作为竞争性内源RNA在心血管疾病中的研究进展

Progress in lncRNA-TUG1 as a competing endogenous RNA in cardiovascular diseases

长链非编码RNA(long no-coding RNA,lncRNA)是指长度超过200个核苷酸的RNA分子,虽然本身并不具备直接编码蛋白质的作用,却可通过参与多种生物过程,包括细胞增殖、分化、凋亡等介导疾病的发生[1]。lncRNA-牛磺酸上调基因1(taurine up-regulated gene 1,TUG1)被认为与人类疾病进展密切[2]。此外,过表达lncRNA-TUG1是心血管疾病后心脏预后不良的生物标志物[3]。

Cardiovascular disease represents the leading cause of death in the world,and early diagnosis and treatment are critical to its prognosis.The lncRNA-taurine up-regulated gene 1(TUG1)mediates a competing endogenous RNA network involved in the development of cardiovascular diseases,involving biological processes such as inflamma tion,immunity,apoptosis,pyroptosis and oxidative stress.This review summarizes the progress of lncRNA-TUG1 as a competing endogenous RNA to mediate the above biological processes in coronary atherosclerotic heart disease,myocardi al ischemia-reperfusion injury,heart failure,hypertension,atrial fibrillation and diabetic cardiomyopathy,to provide a reference for subsequent research on cardiovascular diseases.