摘要
目的 探讨呼吸道病原体感染住院儿童的病原谱特征,为相关感染性疾病的诊治和预防控制提供依据。方法 收集2022年6月至2023年3月深圳市龙岗区妇幼保健院采集住院儿童呼吸道病原体样本2108份,采用多重聚合酶链反应技术对样本进行甲型流行性感冒病毒(influenza A virus,FluA)、乙型流行性感冒病毒(influenza B virus,FluB)、呼吸道合胞病毒(respiratory syncytial virus,RSV)、腺病毒(respiratory adenovirus,ADV)、鼻病毒(respiratory rhinovirus,HRV)、肺炎支原体(mycoplasma pneumoniae,MP)6种病原体检测,分析总体检出情况,并对不同年龄、性别、疾病、月份、时间段的病原体分布特点进行比较。结果 病原体的阳性总检出率为50.05%,单一感染中HRV(333例,15.80%)、RSV(237例,11.24%)、FluA(194例,9.20%)占比较高,混合感染中以HRV与RSV组合频次最高;住院患儿不同年龄组病原体单一感染、混合感染(3种病原体混合感染除外)的阳性检出率差异均有统计学意义(均P<0.05)。不同性别住院患儿病原体单一感染、混合感染的阳性检出率差异均无统计学意义(均P>0.05)。FluA在急性支气管炎患儿中检出率最高(27.24%),支气管肺炎患儿中以RSV阳性检出率最高(19.14%),急性咽炎患儿中以ADV阳性检出率最高(47.06%),喘息性支气管炎患儿中以HRV和RSV阳性检出率最高(50.00%和48.08%),重症肺炎患儿中以MP阳性检出率最高(36.73%)。FluA检出率在2022年7月和2023年3月有2个小高峰,RSV在2022年12月检出率最高,HRV检出率在2022年11月和2023年2月有2个小高峰,ADV和MP每月均有检出。结论 呼吸道感染住院患儿感染的主要病原体是HRV和RSV,同时应注意防控重叠感染。
Objective To explore the pathogenic spectrum characteristics of hospitalized children infected with respiratory pathogens in order to provide a basis for the diagnosis,treatment,prevention and control of related infectious diseases.Method From June 2022 to March 2023,2108 respiratory pathogen samples of hospitalized children were collected in Longgang District Maternal&Child Health Hospital,Shenzhen.Multiple polymerase chain reaction(PCR)was used to detect influenza A virus(FluA),influenza B virus(FluB),respiratory syncytial virus(RSV),adenovirus(ADV),rhinovirus(HRV),and mycoplasma pneumoniae(MP)in the samples,and the overall detection situation was analyzed.The characteristics of pathogen distribution in different age groups,genders,disease diagnoses,months,and time periods were compared.Result The total positive detection rate of pathogens was 50.05%.HRV(333 cases,15.80%),RSV(237 cases,11.24%),and FluA(194 cases,9.20%)accounted for a high proportion of single infections.The combined frequency of HRV and RSV was the highest in mixed infections.There were statistical differences in the positive detection rates of pathogen single infection and mixed infection(except the positive rate of three pathogens)in hospitalized children of different age groups(P<0.05).There was no significant difference in the positive detection rate of pathogen single infection and mixed infection among hospitalized children of different genders(P>0.05).The detection rate of FluA was the highest in children with acute bronchitis(27.24%),RSV was the highest in bronchial pneumonia(19.14%),ADV was the highest in children with acute pharyngitis(47.06%),and HRV and RSV were the highest in children with asthmatic bronchitis(50.00%and 48.08%).The positive rate of MP was the highest in children with severe pneumonia(36.73%).FluA detection rate had two small peaks in July 2022 and March 2023;RSV detection rate was the highest in December 2022;HRV detection rate had two small peaks in November 2022 and February 2023;and ADV and MP were detected every month.Conclusion The main pathogens responsible for infections in hospitalized children with respiratory infections are HRV and RSV,and attention should also be paid to the prevention and control of multiple infections.
作者
曹宪振
马杰彦
胡亮
李高驰
刘维强
Cao Xianzhen;Ma Jieyan;Hu Liang;Li Gaochi;Liu Weiqiang(Centeral Laboratory,Longgang District Maternal&Child Healthcare Hospital of Shenzhen City(Longgang Maternal&Child Institute of Shantou University Medical College),Guangdong Shenzhen 518172,China;Clinical Laboratory,Longgang District Maternal&Child Healthcare Hospital of Shenzhen City(Longgang Maternal&Child Institute of Shantou University Medical College),Guangdong Shenzhen 518172,China)
出处
《新发传染病电子杂志》
2024年第1期12-16,共5页
Electronic Journal of Emerging Infectious Diseases
基金
深圳市龙岗区医疗卫生科技计划项目(LGWJ2021-69)
深圳市龙岗区出生缺陷预防重点实验室(LGKCZSYS2018000010)。
关键词
住院
儿童
呼吸道
感染
病原体
流行病学
Hospitalization
Children
Respiratory tract
Infection
Pathogen
Epidemiology