催产素影响条件化恐惧情绪加工的认知机制及神经基础

Cognitive neural mechanisms underlying the impact of oxytocin on conditioned fear processing

恐惧是一种与进化密切相关的情绪,对人类的生存与适应具有重要价值。过度的恐惧可能会导致恐惧症、焦虑症和创伤后应激障碍等病理性恐惧的产生。而催产素对各种病理性恐惧的干预和治疗具有重要的价值。因此,研究拟采用行为和fMRI技术,系统探究催产素影响条件化恐惧情绪加工的认知神经机制。重点关注:(1)催产素影响恐惧习得的认知神经机制;(2)催产素影响恐惧记忆巩固的认知神经机制;(3)催产素影响恐惧记忆再巩固的认知神经机制;(4)催产素影响恐惧消退的认知神经机制。这项研究的开展对于探究催产素影响条件化恐惧情绪加工的认知神经机制具有很高的科学价值,对于各种病理性恐惧的干预与治疗也具有重要的应用价值。

Fear is a basic emotion that plays an important role in human survival and adaptation.However,excessive fear may lead to conditions such as phobia,anxiety disorder and PTSD.Oxytocin is a promising pharmacological agent to enhance treatment response in fear-related disorders.Therefore,through the combination of behavioral and fMRI research,the project systematically investigated neural mechanisms underlying the impact of oxytocin on fear processing.The contents of this project include:(1)Examining neural mechanisms underlying the impact of oxytocin on fear acquisition;(2)Investigating neural mechanisms underlying the impact of oxytocin on fear consolidation;(3)Exploring neural mechanisms underlying the impact of oxytocin on fear reconsolidation;(4)Studying neural mechanisms underlying the impact of oxytocin on fear extinction.Thus,the implementation of this project will contribute important scientific value to investigation of neural mechanisms underlying the impact of oxytocin on fear processing.Moreover,the findings also provide an approach of potential intervention and treatment for the fear-related disorders.