类风湿关节炎与抑郁症相关性研究进展

Research Progress on the Correlation of Rheumatoid Arthritis and Depression

目的为临床早期诊治类风湿关节炎(RA)及其并发抑郁症提供参考。方法查阅相关文献,就RA与抑郁症的相关性、共同的发病机制进行总结。结果与结论与RA发病一样,抑郁症的发生是多种因素共同作用的结果,其可能与患者心理因素、生活质量、生理因素、免疫调节,以及表观遗传学、肠道微生物和维生素D的吸收有关。但目前RA与抑郁症的发病机制尚不明确,仍有待进一步研究确证。

Objective To provide reference for the early diagnosis and treatment of rheumatoid arthritis(RA)and its concurrent depression in clinical practice.Methods The relevant literatures were reviewed,and the correlation,common pathogenesis between RA and depression were summarized.Results and Conclusion Similar to the incidence of RA,and the occurrence of depression is the result of multiple factors working together,which may be related to the patients'psychological factors,quality of life,physiological factors,immune regulation,as well as epigenetics,intestinal microbiota,and vitamin D absorption.However,the pathogenesis of RA and depression is currently unclear and further research is needed to confirm.