水蛭治疗脑小血管病所致神经功能障碍的疗效及其对相关生物标志物的影响

Efficacy of Leech in Treating Neurological Dysfunction Due to Cerebral Small Vessel Disease and Its Effect on Related Biomarkers

目的探讨水蛭治疗脑小血管病(Cerebral Small Vessel Disease,CSVD)所致神经功能障碍患者的临床疗效。方法选取2020年10月—2023年6月广西壮族自治区民族医院神经内科收治的120例CSVD导致认知功能障碍患者为研究对象,以随机数表法分为对照组(n=60,常规西药内科基础治疗)和观察组(n=60,在对照组基础上增加中药水蛭治疗)。分别于治疗前、治疗2周及治疗3个月后观察两组患者的神经功能障碍评分和血清胱抑素C、同型半胱氨酸、高敏C反应蛋白指标水平。结果与治疗前相比,两组治疗2周、治疗3个月后的神经功能障碍评分以及血清胱抑素C、同型半胱氨酸、高敏C反应蛋白指标水平均明显下降,且观察组治疗3个月后下降幅度更大,差异有统计学意义(P均<0.05)。观察组治疗的总有效率(86.67%)高于对照组(71.67%),差异有统计学意义(χ^(2)=4.093,P<0.05)。结论水蛭能有效改善CSVD所致的神经功能缺损,同时能降低患者血清胱抑素C、同型半胱氨酸、高敏C反应蛋白指标水平。

Objective To explore the clinical efficacy of leech in treating patients with neurological dysfunction caused by cerebral small vessel disease(CSVD).Methods A total of 120 patients with cognitive dysfunction caused by CSVD who were admitted to the Department of Neurology,Guangxi Zhuang Autonomous Region Ethnic Hospital from October 2020 to June 2023 were selected as the research objects.They were divided into the control group(n=60,conventional western medicine basic treatment)and the observation group(n=60,traditional Chinese medicine leech treatment was added on the basis of the control group)by the random number table method.The neurological dysfunction score and serum cystatin C,homocysteine and high-sensitivity C-reactive protein levels were observed be⁃fore treatment,2 weeks and 3 months after treatment.Results Compared with before treatment,the neurological dys⁃function scores and serum cystatin C,homocysteine and high-sensitivity C-reactive protein levels of the two groups af⁃ter 2 weeks and 3 months of treatment were significantly decreased,and the observation group decreased more significantly after 3 months of treatment,and the differences were statistically significant(all P<0.05).The total effective rate of the observation group(86.67%)was higher than that of the control group(71.67%),the difference was statisti⁃cally significant(χ2=4.093,P<0.05).Conclusion Leech can effectively improve the neurological deficits caused by CSVD,and at the same time can reduce the level of serum cystatin C,homocysteine,and high-sensitivity C-reactive protein indexes in patients.