DCLK1单克隆抗体在结直肠癌中的表达以及影响因素分析

Expression of DCLK1 Monoclonal Antibody in Colorectal Cancer and Its Influencing Factors

目的研究和分析Doublecortin样激酶-1(Doublecortin Like Disease 1,DCLK1)单克隆抗体在结肠癌中的表达情况与相关影响因素。方法选取2018年7月—2022年6月哈尔滨工业大学附属黑龙江省医院收治的73例结直肠癌患者作为研究对象,根据患者肿瘤组织中DCLK1表达水平,将其分为DCLK1低表达组(n=31)与DCLK1高表达组(n=42),分析DCLK1单克隆抗体在结直肠癌中表达的影响因素。结果DCLK1高表达组与DCLK1低表达组肿瘤直径、肿瘤分期(Tumor Node Metastasis,TNM)、浸润深度、淋巴结是否转移、有无脉管、肿瘤病灶是否远处转移及肿瘤分化程度对比,差异有统计学意义(P均<0.05)。多因素Logistic回归分析研究结果表明,肿瘤组织中DCLK1高表达水平影响因素包括淋巴结转移、浸润深度、TNM分期、肿瘤直径、肿瘤病灶远处转移、肿瘤分化程度(OR=1.079、1.235、1.548、1.784、1.745、2.026,P均<0.05)。结论肿瘤组织中DCLK1高表达水平影响因素包括淋巴结转移、浸润深度、TNM分期、肿瘤直径、肿瘤病灶远处转移、肿瘤分化程度,临床可通过检测上述指标的方式判断肿瘤组织中DCLK1表达水平。

Objective To study and analyze the expression of doublecortin like disease 1(DCLK1)monoclonal anti⁃body in colon cancer and related influencing factors.Methods Seventy-three patients with colorectal cancer admitted to Heilongjiang Provincial Hospital Affiliated to Harbin Institute of Technology from July 2018 to June 2022 were se⁃lected as the study objects.According to the expression level of DCLK1 in tumor tissues of patients,they were divided into low expression group of DCLK1(n=31)and high expression group of DCLK1(n=42).Analyzed the influencing factors of DCLK1 monoclonal antibody expression in colorectal cancer.Results There were statistically significant differ⁃ences in tumer diameter tumor node metastasis(TNM),depth of invasion,lymph node metastasis,vasculature,distant metastasis and degree of tumor differentiation between high DCLK1 expression group and low DCLK1 expression group(all P<0.05).Multivariate Logistic regression analysis showed that the factors affecting the high expression level of DCLK1 in tumor tissues included lymph node metastasis,depth of invasion,TNM stage,tumor diameter,distant me⁃tastasis of tumor lesions,and degree of tumor differentiation(OR=1.079,1.235,1.548,1.784,1.745,2.026,all P<0.05).Conclusion Factors influencing the high expression level of DCLK1 in tumor tissues include lymph node metas⁃tasis,depth of invasion,TNM stage,tumor diameter,distant metastasis of tumor lesions,and degree of tumor differen⁃tiation.Clinically,the expression level of DCLK1 in tumor tissues can be determined by detecting the above indica⁃tors.