疏血通配合艾地苯醌治疗对脑梗死伴血管性认知障碍患者神经电生理指标、认知功能的影响

Effect of Shuxuetong Combined with Idibenquinone on Neuroelectrophysiological Indexes and Cognitive Function in Patients with Cerebral Infarction and Vascular Cognitive Impairment

目的分析疏血通与艾地苯醌配合治疗脑梗死伴血管性认知障碍(Vascular Cognitive Impairment,VCI)的作用。方法选择2021年10月—2022年10月兰陵县人民医院收治的脑梗死伴VCI患者84例为研究对象,采用随机数表法分为观察组对照组(n=42,艾地苯醌治疗)和(n=42,在对照组基础上联合疏血通治疗)。对比两组认知功能、神经电生理指标、神经功能、不良反应、日常生活能力。结果治疗后,观察组(δ+θ)/(α+β)为(0.96±0.13)、P300潜伏期为(275.92±24.18)ms低于对照组,P300波幅(5.35±0.84)μV高于对照组,差异有统计学意义(t=19.133、8.242、2.548,P均<0.05)。治疗后,观察组蒙特利尔认知评估量表评分为(22.43±1.55)分、简易精神状态检查量表(23.24±3.38)分,高于对照组的(17.97±2.66)分、(19.18±3.27)分,美国国立卫生研究院卒中量表评分为(12.31±2.54)分,低于对照组(17.52±3.31)分,Barthel指数(70.49±4.18)分,高于对照组(63.24±4.22)分,差异有统计学意义(t=9.389、5.595、8.093、7.910,P均<0.05)。观察组不良反应发生率为14.29%,高于对照组的9.52%,差异无统计学意义(χ^(2)=0.454,P>0.05)。结论在脑梗死伴VCI中,疏血通与艾地苯醌配合治疗能够有效促进其神经功能改善,提高认知功能、日常生活能力,调节神经电生理指标,且不良反应少。

Objective To analyze the effect of Shuxuetong and Idebenquinone in the treatment of cerebral infarction with vascular cognitive impairment(VCI).Methods A total of 84 patients with cerebral infarction and VCI treated in Lanling County People's Hospital from October 2021 to October 2022 were selected as the study objects,and were di⁃vided into control group(n=42,combined with idbenquinone treatment)and observation group(n=42,combined with Shuxuetong treatment on the basis of control group)by random number table method.Cognitive function,neuroelectro⁃physiological indexes,nerve function,adverse reactions and daily living ability were compared between the two groups.Results After treatment,the(δ+θ)/(α+β)of the observation group was(0.96±0.13),the P300 latency was(275.92±24.18)ms,lower than those of the control group,and the P300 amplitude was(5.35±0.84)μV,higher than that of the control group,the differences were statistically significant(t=19.133,8.242,2.548,all P<0.05).After treat⁃ment,the scores of Montreal Cognitive Assessment Scale(22.43±1.55)points and Simple Mental State Examination Scale(23.24±3.38)points in the observation group were higher than those of control group(17.97±2.66)points and control group(19.18±3.27)points,the National Institutes of Health Stroke Scale score was(12.31±2.54)points,lower than that of the control group(17.52±3.31)points,and the was(70.49±4.18)points,higher than that of the control group(63.24±4.22)points,the differences were statistically significant(t=9.389,5.595,8.093,7.910,all P<0.05).The incidence of adverse reactions in observation group was 14.29%,higher than that in control group(9.52%),with no sig⁃nificant difference(χ^(2)=0.454,P>0.05).Conclusion In cerebral infarction with VCI,Shuxuetong combined with idiben⁃quinone can effectively promote the improvement of nerve function,improve cognitive function,daily living ability,regulate nerve electrophysiological indexes,and less adverse reactions.