长期小剂量阿奇霉素联合异丙托溴铵治疗COPD稳定期患者的临床疗效及其对肺功能的影响

Clinical Efficacy of Long-term Low-dose Azithromycin Combined with Ipratropium Bromide in Stable COPD Patients and Its Effect on Lung Function

目的探讨小剂量阿奇霉素联合异丙托溴铵治疗稳定期慢性阻塞性肺疾病患者的临床效果。方法选取2021年6月—2022年12月徐州矿山医院呼吸内科接收的70例稳定期慢性阻塞性肺疾病患者为研究对象,根据随机数表法分成对照组和观察组,各35例。对照组患者采用异丙托溴铵雾化治疗,观察组患者采用小剂量阿奇霉素口服联合异丙托溴铵雾化治疗,比较两组疗效、第一秒用力呼气容积、用力肺活量、C反应蛋白(C Reactive Protein,CRP)、降钙素原(Procalcitonin,PCT)、白介素-6(Interleukin-6,IL-6)水平以及不良反应发生情况。结果观察组疗效为94.29%,高于对照组的74.29%,差异有统计学意义(χ^(2)=5.285,P=0.022),且在治疗后观察组患者的肺功能各项均高于对照组,观察组患者治疗后血清CRP、PCT、IL-6水平低于对照组,差异有统计学意义(P均<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论稳定期慢性阻塞性肺疾病患者采用小剂量阿奇霉素联合异丙托溴铵雾化治疗,可提升患者肺部功能,增强治疗效果。

Objective To investigate the clinical effect of low-dose azithromycin combined with ipratropium bromide in the treatment of patients with stable chronic obstructive pulmonary disease.Methods Seventy patients with stable chronic obstructive pulmonary disease admitted to Department of Respiratory Medicine of Xuzhou Mining Hospital from June 2021 to December 2022 were selected as the study objects and were divided into control group and observa⁃tion group according to random number table method,with thirty-five patients in each group.Control group was treated with ipratropium bromide atomization,observation group was treated with low-dose azithromycin combined with ipratropium bromide atomization.The efficacy,force expiratory volume in one second,forced vital capacity,C re⁃active protein(CRP),procalcitonin(PCT),interleukin-6(IL-6)levels and adverse reaction occurrence were compared between the two groups.Results The curative effect of observation group was 94.29%,which was higher than that of control group(74.29%),and the difference was statistically significant(χ^(2)=5.285,P=0.022).After treatment,the levels of pulmonary function in observation group were higher than those in control group,while the levels of serum CRP,PCT and IL-6 in observation group were lower than those in control group,the difference was statistically significant(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Low-dose azithromycin combined with ipratropium bromide atomization in patients with stable chronic obstructive pulmonary disease can improve the lung function and enhance the therapeutic effect.