脑梗死血管介入后应用依达拉奉右莰醇药物的临床疗效

Clinical Effect of Edaravone Dextrocamphenol after Cerebral Infarction Vascular Intervention

目的探讨脑梗死患者在基础治疗血管介入术后,应用药物依达拉奉右莰醇注射液治疗的临床效果及意义。方法选取2021年8月—2023年4月菏泽市成武县人民医院收治的80例脑梗死患者作为研究对象,根据治疗药物的不同分为研究组(n=40)和对照组(n=40)。两组患者均接受血管介入术治疗,对照组在术后使用依达拉奉,研究组在术后使用依达拉奉右莰醇注射液,比较两组患者的国立卫生研究院卒中量表评分、改良Rankin量表(Modified Rankin Scale,mRS)评分及血清指标(一氧化氮、超氧化物歧化酶、活性氧簇)水平。结果治疗15 d后,研究组国立卫生研究院卒中量表评分为(4.59±0.77)分,低于对照组的(5.17±0.91)分,差异有统计学意义(t=3.077,P<0.05);治疗15 d,研究组一氧化氮、超氧化物歧化酶水平低于对照组,差异有统计学意义(P均<0.05);治疗15 d,研究组活性氧簇水平低于对照组,差异有统计学意义(t=6.138,P<0.05)。结论脑梗死患者在血管介入术基础上再配合应用依达拉奉右莰醇注射液治疗临床效果十分显著,这种综合治疗方案显著提高了患者的神经功能评分及血清相关因子水平。

Objective To investigate the clinical effect and significance of edaravone dextrocamphorol injection in pa⁃tients with cerebral infarction after basic therapy vascular intervention.Methods 80 patients with cerebral infarction who received in Chengwu County People's Hospital of Heze City from August 2021 to April 2023 were selected as the study objects.They were divided into study group(n=40)and control group(n=40).Patients in both groups received vascular interventional therapy,the control group received postoperative edaravone,and the study group received post⁃operative Edaravone dexcamphorol injection.The scores of National Institutes of Health Stroke Scale,Modified Rankin Scale(mRS)and the levels of serum indicators(nitric oxide,superoxide dismutase,reactive oxygen species)of the two groups of patients were compared.Results After 15 d of treatment,the score of the National Institutes of Health Stroke Scale in the study group was(4.59±0.77)points,which was lower than that in the control group(5.17±0.91)points,and the difference was statistically significant(t=3.077,P<0.05).After 15 d of treatment,the levels of ni⁃tric oxide and superoxide dismutase in the study group were lower than those in the control group,and the differences were statistically significant(both P<0.05).After 15 d of treatment,the level of reactive oxygen species in study group was lower than that in control group,and the difference was statistically significant(t=6.138,P<0.05).Conclusion In patients with cerebral infarction,vascular intervention combined with edaravone dextrocamphorol injection has a remarkable clinical effect,this comprehensive treatment program significantly improves the neurological function scores and serum related factors.