经桡动脉行PCI术联合术后伊伐布雷定对冠心病患者疗效及对冠脉再狭窄发生率、血清ET水平的影响

Efficacy of Transradial Artery PCI Combined with Postoperative Ivabradine in Patients with Coronary Artery Disease and Effects on the Incidence of Coronary Restenosis and Serum ET Levels

目的探讨经桡动脉行PCI术联合术后伊伐布雷定对冠心病患者疗效及对冠脉再狭窄发生率、血清内皮素(Endothelin,ET)水平的影响。方法选取2021年1月—2022年8月贵州省纳雍县人民医院经桡动脉行PCI术的120例冠心病患者为研究对象,按照随机数表法分为对照组和观察组,各60例。对照组术后给予常规治疗,观察组在此基础上联合伊伐布雷定治疗。比较两组患者的临床资料、手术指标、疗效(有效率、炎性反应、复发心绞痛率)、冠脉再狭窄发生率及血清ET水平。结果与对照组(76.67%)相比,观察组的治疗有效率(93.33%)更高,差异有统计学意义(χ^(2)=6.614,P<0.05);观察组的C-反应蛋白、白细胞计数、心绞痛复发率、冠脉再狭窄率、血清ET水平均低于对照组,差异有统计学意义(P均<0.05)。结论经桡动脉行PCI术联合术后伊伐布雷定能够提高冠心病患者的临床疗效,降低冠脉再狭窄发生率,降低血清ET水平。

Objective To investigate the efficacy of transradial artery PCI combined with postoperative ivabradine in patients with coronary artery disease and its effect on the incidence of coronary restenosis and serum endothelin(ET)level.Methods A total of 120 patients with coronary heart disease who underwent transradial PCI in Guizhou Nayong County People's Hospital from January 2021 to August 2022 were selected as the study objects,and they were divided into control group and observation group according to random number table method,with 60 cases in each group.The control group was given conventional treatment after operation,and the observation group was treated with ivabradine.The clinical data,surgical indexes,curative effect(effective rate,inflammatory response,recurrence rate of angina pec⁃toris),incidence of coronary restenosis and serum ET level were compared between the two groups.Results Compared with the control group(76.67%),the effective rate of the observation group(93.33%)was higher,and the difference was statistically significant(χ^(2)=6.614,P<0.05).The C-reactive protein,white blood cell count,angina recurrence rate,coronary restenosis rate and serum ET level in observation group were lower than those in control group,and the differences were statistically significant(all P<0.05).Conclusion Transradial artery PCI combined with postoperative ivabradine can improve the clinical efficacy of patients with coronary artery disease,reduce the incidence of coronary restenosis,and reduce the serum ET level.