多潘立酮及消化酶联合治疗消化不良的临床效果观察

Observation on the Clinical Effect of Combined Treatment of Dyspepsia with Domperidone and Digestive Enzyme

目的探讨多潘立酮联合消化酶治疗消化不良的临床效果。方法选取2021年2月—2023年2月四川护理职业学院附属医院消化内科收治的208例消化不良患者为研究对象,按随机数表法分为两组,各104例。对照组给予多潘立酮治疗,观察组联合给予消化酶治疗,比较两组临床疗效,记录患者症状消退时间,测定治疗前、治疗后患者的血清胃肠激素、胃蛋白酶原(Pepsinogen,PG)水平,观察不良反应发生情况。结果观察组治疗总有效率(96.15%)明显高于对照组(85.58%),差异有统计学意义(χ^(2)=7.008,P<0.05);观察组早饱消退时间、腹胀消退时间、烧心消退时间、嗳气消退时间、腹痛消退时间均明显低于对照组,差异有统计学意义(t=14.833、12.782、16.371、16.373、30.650,P均<0.05);治疗后,两组血清胃肠激素明显改善,观察组促胃泌素、促胃动素、血浆瘦素水平明显高于对照组,差异有统计学意义(t=7.531、38.018、8.463,P均<0.05),胆囊收缩素、生长抑素、促肾上腺皮质激素释放激素水平明显低于对照组,差异有统计学意义(t=9.544、9.266、19.246,P均<0.05);治疗后,观察组PGⅠ、PGⅡ、胃蛋白酶原比值水平均明显高于对照组,差异有统计学意义(t=13.889、3.974、6.791,P均<0.05)。观察组不良反应发生率(4.81%)与对照组(5.77%)相比,差异无统计学意义(χ^(2)=0.096,P=0.756)。结论针对消化不良患者采取多潘立酮联合消化酶治疗可促进胃肠症状快速消退,改善消化功能,促进胃肠运动,取得良好的治疗效果,而且联合用药安全,不良反应少。

Objective To explore the clinical effect of domperidone combined with digestive enzymes in the treatment of dyspepsia.Methods A total of 208 patients with dyspepsia admitted to the gastroenterology department of the Affili⁃ated Hospital of Sichuan Nursing Vocational College from February 2021 to February 2023 were selected as the study objects,and they were divided into two groups according to random number table method,with 104 patients in each group.The control group was treated with domperidone,and the observation group received combined treatment with digestive enzymes.The clinical efficacy of the two groups was compared,the time of symptom disappearance was re⁃corded,the levels of serum gastrointestinal hormones and pepsinogen(PG)were measured before and after treatment,and the occurrence of adverse reactions was observed.Results The total effective rate of the observation group was 96.15%,which was significantly higher than 85.58%of the control group,and the difference was statistically significant(χ^(2)=7.008,P<0.05).The time of early satiety subsiding,abdominal distension subsiding,heartburn subsiding,belching subsiding and abdominal pain subsiding in the observation group were significantly lower than those in the control group,and the differences were statistically significant(t=14.833,12.782,16.371,16.373,30.650,all P<0.05).After treatment,the serum gastrointestinal hormones of the two groups were significantly improved.The levels of gas⁃trin,motilin and leptin in the observation group were significantly higher than those in the control group,and the dif⁃ferences were statistically significant(t=7.531,38.018,8.463,all P<0.05).The levels of cholecystokinin,somatostatin and corticotropin-releasing hormone were significantly lower than those of the control group,and the differences were statistically significant(t=9.544,9.266,19.246,all P<0.05).After treatment,the levels of PGⅠ,PGⅡand pepsino⁃gen ratio in the observation group were significantly higher than those in the control group,and the differences were statistically significant(t=13.889,3.974,6.791,all P<0.05).There was no significant difference in the incidence of ad⁃verse reactions between the observation group(4.81%)and the control group(5.77%)(χ^(2)=0.096,P=0.756).Conclu⁃sion Domperidone combined with digestive enzyme treatment for patients with dyspepsia can promote the rapid subsid⁃ence of gastrointestinal symptoms,improve digestive function,promote gastrointestinal motility,and achieve good therapeutic effects,and the combination of drugs is safe,with fewer adverse reactions.