厄贝沙坦氢氯噻嗪联合美托洛尔治疗慢性充血性心衰的效果分析与探究

Analysis and Investigation of the Effectiveness of Irbesartan Hydrochlorothiazide Combined with Metoprolol in the Treatment of Chronic Congestive Heart Failure

目的分析慢性充血性心衰实施厄贝沙坦氢氯噻嗪+美托洛尔治疗的效果。方法将2020年11月—2023年11月正定二五六医院综合内科200例慢性充血性心衰患者作为研究对象,掷骰子分组,分为参考组、实践组,各100例,参考组行厄贝沙坦氢氯噻嗪治疗,实践组增加美托洛尔治疗。比较两组疗效、左心室功能、转归情况和不良反应。结果实践组治疗总有效率(98.00%)高于参考组的91.00%,差异有统计学意义(χ^(2)=4.714,P<0.05)。治疗后,实践组左心室射血分数高于参考组,左室舒张末期内径低于参考组,差异有统计学意义(P均<0.05)。治疗后,实践组6 min步行试验高于参考组,B型利钠肽原低于参考组,差异有统计学意义(P均<0.05)。两组不良反应对比,差异无统计学意义(P>0.05)。结论厄贝沙坦氢氯噻嗪+美托洛尔共同使用后的患者不良反应较少,能切实改善左心室功能,减轻心肌损伤,提高治疗有效率,对慢性充血性心衰较适用。

Objective To analyze the effect of implementing irbesartan hydrochlorothiazide+metoprolol treatment for chronic congestive heart failure.Methods 200 cases of chronic congestive heart failure patients in the comprehensive internal medicine department of Zhengding 256 Hospital from November 2020 to November 2023 were taken as re⁃search subjects,and rolled the dice to group them into reference group and practice group,each with 100 cases.The reference group carried out the treatment of irbesartan hydrochlorothiazide,and the practice group increased the treat⁃ment of metoprolol.The efficacy,left ventricular function,regression and count adverse reactions were compared of the two groups.Results The total effective rate of 98.00%in the practice group was higher than 91.00%in the refer⁃ence group,and the difference was statistically significant(χ^(2)=4.714,P<0.05).After treatment,the left ventricular ejection fraction of the practice group was higher than that of the reference group,and the left ventricular enddiastolic internal diameter was lower than that of the reference group,and the differences were statistically significant(both P<0.05).After treatment,the 6 min walking test of the practice group was higher than that of the reference group,and the B-type natriuretic peptideogen was lower than that of the reference group,and the differences were statistically significant(both P<0.05).Comparison of adverse reactions between the two groups,the difference was not sta⁃tistically significant(P>0.05).Conclusion Irbesartan hydrochlorothiazide+metoprolol after co-administration of fewer adverse reactions,can effectively improve the left ventricular function,reduce myocardial injury,and improve the efficiency,and this treatment method is more applicable to chronic congestive heart failure.