肿瘤标志物联合HER-2在原发性胃癌患者中的诊断效能

Diagnostic Efficacy of Tumor Markers Combined with HER-2 in Patients with Primary Gastric Cancer

目的研究分析原发性胃癌患者诊断中联合人表皮生长因子受体2(Human Epidermal Growth Factor Receptor 2,HER-2)的临床价值。方法将2017年6月—2023年1月在徐州医科大学附属邳州医院接受治疗的60例原发性胃癌患者选为观察组,将同期接受体检的60例健康者选为参照组。两组均给予肿瘤标志物水平、HER-2水平检验,对比两组肿瘤标志物水平、HER-2水平,以及肿瘤标志物诊断、HER-2诊断、肿瘤标志物联合HER-2诊断的准确度、灵敏度、特异度。结果观察组糖类抗原19-9、糖类抗原125、糖类抗原72-4、癌胚抗原、HER-2水平分别为(50.37±5.42)U/mL、(49.63±5.29)U/mL、(11.69±2.42)U/mL、(17.53±3.28)ng/mL、(20.65±3.58)ng/mL,明显高于参照组,差异有统计学意义(t=60.451、59.408、30.833、35.147、18.848,P均<0.05)。肿瘤标志物联合HER-2诊断原发性胃癌的灵敏度与准确度分别为98.33%、97.50%,高于肿瘤标志物和HER-2单一诊断,差异有统计学意义(P均<0.05)。结论肿瘤标志物与HER-2均可用于诊断原发性胃癌,两者联合的诊断效能更高。

Objective To study and analyze the clinical value of human epidermal growth factor receptor 2(HER-2)combined with human epidermal growth factor receptor 2 in the diagnosis of primary gastric cancer patients.Methods Sixty patients with primary gastric cancer who received treatment in Xuzhou Medical University Affiliated Pizhou Hos⁃pital from June 2017 to January 2023 were selected as the observation group,and sixty healthy subjects who under⁃went physical examination during the same period were selected as the reference group.Tumor marker level and HER-2 level were tested in both groups.The accuracy,sensitivity and specificity of tumor marker level,HER-2 level and tumor marker diagnosis,HER-2 diagnosis and tumor marker combined with HER-2 diagnosis were compared be⁃tween the two groups.Results The levels of carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 125(CA125),carbohydrate antigen 72-4(CA72-4),carcinoembryonic antigen(CEA)and HER-2 in the observation group were(50.37±5.42)U/mL,(49.63±5.29)U/mL and(11.69±2.42)U/mL,(17.53±3.28)ng/mL,(20.65±3.58)ng/mL,signifi⁃cantly higher than those in the reference group,and the differences were statistically significant(t=60.451,59.408,30.833,35.147,18.848,all P<0.05).The sensitivity and accuracy of tumor marker combined with HER-2 in the diag⁃nosis of primary gastric cancer were 98.33%and 97.50%,respectively,higher than those of tumor marker combined with HER-2 alone,the differences were statistically significant(both P<0.05).Conclusion Both tumor markers and HER-2 can be used in the diagnosis of primary gastric cancer,and the combination of the two has a higher diagnostic efficiency.