自拟枣藤安神汤治疗肝郁血虚型失眠的疗效分析

Analysis of the Efficacy of Self-designed Zaoteng Anshen Decoction in Treating Insomnia of Liver Depression and Blood Deficiency Type

目的探讨自拟枣藤安神汤治疗肝郁血虚型失眠的治疗效果。方法方便选取2019年11月—2022年10月陕西省榆林市第五医院收治的122例肝郁血虚型失眠患者为研究对象,随机数表法分两组。对照组(61例)采取艾司唑仑片治疗,观察组(61例)在对照组基础上增加自拟枣藤安神汤治疗,对比两组临床疗效,中医证候积分、睡眠质量、脑源性神经生长因子(Brain Derived Nerve Growth Factor,BDNF)及5-羟色胺(5-hydroxytryptamine,5-HT)水平及不良反应。结果观察组治疗总有效率(91.80%)高于对照组(78.69%),差异有统计学意义(χ^(2)=4.171,P<0.05)。治疗后,观察组入睡困难或易早醒、心烦易怒、乏力、悲伤欲哭、寐后易惊、气短倦怠等积分均低于对照组,差异有统计学意义(P均<0.05);治疗后,观察组睡眠质量评分低于对照组,差异有统计学意义(P<0.05);治疗后,观察组BDNF与5-HT水平高于对照组,差异有统计学意义(P均<0.05);两组不良反应对比,差异无统计学意义(P>0.05)。结论自拟枣藤安神汤治疗肝郁血虚型失眠能改善患者临床症状,对睡眠质量的提高和神经功能的改善有积极作用,且安全性较高。

Objective To explore the therapeutic effect of self-designed Zaoteng Anshen decoction in treating insom⁃nia of liver depression and blood deficiency type.Methods A total of 122 insomnia patients with liver depression and blood deficiency treated in the Fifth Hospital of Yulin,Shaanxi Province from November 2019 to October 2022 were conveniently selected as the study objects,and divided into two groups by random number table method.The control group(61 cases)was treated with Esazolam tablets,and the observation group(61 cases)was treated with selfprepared Zaoteng Anshen decoction.Clinical efficacy,TCM syndrome score,sleep quality,brain derived nerve growth factor(BDNF)and 5-hydroxytryptamine(5-HT)levels and adverse reactions were compared between the two groups.Results The total effective rate of observation group(91.80%)was higher than that of control group(78.69%),and the difference was statistically significant(χ^(2)=4.171,P<0.05).After treatment,the scores of the observation group were lower than those of the control group,such as difficulty in falling asleep or waking up early,irritability,fatigue,sad⁃ness and crying,easy to panic after sleep,shortness of breath and burnout,the differences were statistically significant(all P<0.05).After treatment,the scores of sleep quality in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).After treatment,the levels of BDNF and 5-HT in observa⁃tion group were higher than those in control group,and the differences were statistically significant(both P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Self-designed Zaoteng Anshen decoction for the treatment of insomnia of liver depression and blood deficiency type can improve the clinical symptoms of the patients,and has a positive effect on the improvement of sleep quality and neurological func⁃tion,and it has a high level of safety.