沙库巴曲缬沙坦对慢性心衰伴高血压患者的疗效及心功能的影响

Effect of Sacubactril Valsartan on Chronic Heart Failure with Hypertension and Its Effects on Cardiac Function

目的分析沙库巴曲缬沙坦治疗慢性心衰伴高血压患者的疗效及对心功能的影响。方法随机选取2021年1月—2022年12月邹城市人民医院治疗的150例慢性心衰伴高血压患者为研究对象,采用双盲法分为两组,每组75例。对照组采取常规疗法,观察组采取常规疗法联合沙库巴曲缬沙坦治疗,比较两组患者临床治疗效果、不良反应发生率、肾功能指标和心功能指标。结果治疗后,观察组患者不良反应发生率9.33%低于对照组的21.33%,差异有统计学意义(χ^(2)=4.160,P<0.05)。治疗后,观察组血肌酐、尿素氮、脑利钠肽水平均低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组左心室射血分数高于对照组,左心室舒张末期内径、左心室收缩末期内径均低于对照组,差异有统计学意义(P均<0.05)。结论慢性心衰伴高血压患者使用沙库巴曲缬沙坦治疗,能够明显改善患者心功能、肾功能水平,且不良反应发生率较低。

Objective To treat patients with chronic heart failure and hypertension with the drug sacubactril valsartan,and to analyze the efficacy and effect of this drug on cardiac function.Methods A total of 150 patients with chronic heart failure and hypertension treated by Zoucheng People's Hospital from January 2021 to December 2022 were ran⁃domly selected and divided into two groups by double-blind method,with 75 patients in each group.The control group was treated with conventional therapy,and the observation group was treated with conventional therapy com⁃bined with the drug sacubactril valsartan.The clinical therapeutic effect,incidence of adverse reactions,renal function indexes and cardiac function indexes were compared between the two groups.Results After treatment,the incidence of adverse reactions in observation group was 9.33%lower than that in control group 21.33%,the difference was statisti⁃cally significant(χ^(2)=4.160,P<0.05).After treatment,the levels of serum creatinine,urea nitrogen and brain natri⁃uretic peptide in the observation group were lower than those in the control group,the differences were statistically sig⁃nificant(all P<0.05).After treatment,left ventricular ejection fraction in observation group was higher than control group,and left ventricular end-diastolic diameter and left ventricular end-systolic diameter were lower than control group,the differences were statistically significant(all P<0.05).Conclusion In the treatment of chronic heart failure patients with hypertension,the use of the drug sacubactril valsartan can significantly improve the level of cardiac func⁃tion and renal function related indicators of patients,and the incidence of adverse reactions was low.