缬沙坦联合氢氯噻嗪在高血压心脏病患者康复治疗中的临床价值

Clinical Value of Valsartan Combined with Hydrochlorothiazide in the Rehabilitation of Patients with Hypertensive Heart Disease

目的分析缬沙坦联合氢氯噻嗪治疗高血压心脏病的效果。方法随机选取2022年6月—2023年6月闽侯县人民医院收治的60例高血压心脏病患者为研究对象,按随机数表法分为对照组和观察组,各30例。两组均给予常规治疗,对照组在常规治疗基础上加用缬沙坦胶囊,观察组在对照组基础上应用氢氯噻嗪。比较两组治疗效果。结果治疗3个月后,观察组24 h平均收缩压、24 h平均舒张压均低于对照组,差异有统计学意义(P均<0.05)。观察组左室射血分数高于对照组,左室后壁厚度、左室间隔厚度、左室重量指数低于对照组,差异有统计学意义(P均<0.05)。观察组内皮素-1低于对照组,一氧化氮高于对照组,差异有统计学意义(P均<0.05)。观察组血清白介素-6、肿瘤坏死因子-ɑ、高敏C反应蛋白水平低于对照组,差异有统计学意义(P均<0.05)。观察组不良反应发生率(10.00%)低于对照组,差异有统计学意义(χ^(2)=4.812,P<0.05)。结论缬沙坦联合氢氯噻嗪可有效改善高血压心脏病患者血压水平和心功能,调节血管内皮功能,减轻机体炎症反应,降低不良反应发生率。

Objective To analyze the effect of valsartan combined with hydrochlorothiazide in the treatment of hypertensive heart disease.Methods 60 cases of hypertensive heart disease patients admitted to Minhou County People's Hospital from June 2022 to June 2023 were randomly selected as the research objects and divided into the control group and the observation group according to the method of random number table,30 cases each.Both groups were given conventional treatment,the control group added valsartan capsules on the basis of conventional treatment,and the observation group applied hydrochlorothiazide on the basis of the control group.Compared the treatment effect of the two groups.Results After 3 months of treatment,the 24-hour mean systolic blood pressure and 24-hour mean diastolic blood pressure of the observation group were lower than those of the control group,and the differences were statistically significant(both P<0.05).The left ventricular ejection fraction of the observation group was higher than that of the control group,and the thickness of the posterior wall of the left ventricle,the thickness of the left ventricular septum,and the mass index of the left ventricle were lower than those of the control group,and the differences were statistically significant(all P<0.05).Endothelin-1 in the observation group was lower than that in the control group,and nitric oxide was higher than that in the control group,and the differences were statistically significant(both P<0.05).Serum interleukin-6,tumor necrosis factor-ɑ,and high-sensitivity C-reactive protein levels were lower in the observation group than in the control group,and the differences were statistically significant(all P<0.05).The incidence of adverse reactions in the observation group(10.00%)was lower than that in the control group,and the difference was statistically significant(χ^(2)=4.812,P<0.05).Conclusion Valsartan combined with hydrochlorothiazide can effectively improve the blood pressure level and cardiac function of hypertensive heart disease patients,regulate the function of vascular endothelium,reduce the inflammatory response of the body,and reduce the adverse reactions.