免疫联合化疗序贯手术应用于局部晚期食管癌的临床疗效

Clinical efficacy of immunotherapy combined with chemotherapy sequential surgery for locally advanced esophageal cancer

目的探索替雷利珠单抗联合化疗序贯手术对局部晚期食管癌的疗效及安全性。方法2018年8月~2022年6月我院收治的局部晚期食管癌病人共60例,根据治疗方法将免疫联合化疗序贯手术病人作为观察组(29例),化疗序贯手术病人为对照组(31例),比较两组临床疗效及安全性。结果观察组R0切除28例,14例达到ORR;对照组R0切除29例,7例达到ORR。观察组ORR病人占比高于对照组,差异有统计学意义(P<0.05)。观察组pCR9例,对照组pCR2例,两组pCR病人占比比较,差异有统计学意义(P<0.05)。两组病人术前及术后不良事件比较,差异无统计学意义。结论免疫检查点抑制剂联合化疗序贯手术对局部晚期食管癌病人安全可靠,短期疗效显著,长期疗效有待观察。

Objective To explore the safety and efficiency of sequential operation of Tirelizumab combined with chemotherapy in neoadjuvant therapy for locally advanced esophageal cancer.Methods A retrospective analysis was conducted on 60 patients with locally advanced esophageal cancer admitted to Renmin Hospital of Wuhan University from August 2018 to June 2022.The immunotherapy combined with chemotherapy sequential surgery patients were selected as the observation group(29 cases)and the chemotherapy sequential surgery patients were selected as the control group(31 cases)according to the treatment method.The study aimed to analyze whether there were differences in efficacy and safety between the two groups.Results There are 28 patients with R0 resection in the observation group,and 14 case reached ORR.In the control group,29 cases were resected with R0,and 7 cases reached ORR.The proportion of ORR patients in the observation group was significantly higher than that in the control group,which was statistically significant(P<0.05).There were 9 patients with pCR in the observation group and 2 patients with pCR in the control group,and the proportion of pCR patients in the two groups was significantly different(P<0.05).There were no significant differences between the two groups for preoperative and postoperative adverse events.Conclusion Immune checkpoint inhibitors combined with chemotherapy sequential surgery are safe and reliable in patients with locally advanced esophageal cancer,with significant short⁃term efficacy,and long⁃term efficacy remains to be observed.