原发性肝癌合并肝硬化门静脉高压症腹腔镜断流术同期联合肝切除或射频消融手术腹腔感染危险因素分析

Analysis of risk factors of intraperitoneal infection after laparoscopic surgery for hepatocellular carcinoma with cirrhosis and portal hypertension

目的分析原发性肝癌合并肝硬化门静脉高压症腹腔镜同期断流术联合肝切除或射频消融手术腹腔感染发生情况与危险因素。方法2017年1月~2022年2月我院收治原发性肝癌(hepatocellular carcinoma,HCC)合并肝硬化门静脉高压症(portal hypertension,PHT)病人105例,行腹腔镜断流联合肝切除或射频消融治疗,观察手术恢复情况,术后腹腔感染发生情况。单因素与Logistic回归多因素分析,筛选术后腹腔感染独立危险因素。结果术后腹腔感染发生率为17.14%。糖尿病、术前MELD评分、术中出血和术后大量腹水为腹腔感染独立危险因素(P<0.05)。结论应加强肝功能维护,术中出血控制,减轻第三间隙积液及糖尿病病人血糖管理,以降低术后腹腔感染。

Objective To analyze the incidence and risk factors of intraperitoneal infection in patients with hepatocellular carcinoma combined with cirrhosis and portal hypertension undergoing laparoscopic surgery.Methods The clinical data of 105 consecutive cases of laparoscopic devascularization combined with hepatectomy or radiofrequency ablation were retrospectively analyzed.The factors that may cause intraperitoneal infection were recorded.The postoperative recovery was observed and the incidence of intraperitoneal infection was recorded.Single factor and logistic regression multivariate analysis were used to screen independent risk factors for intraperitoneal infection.Results The incidence of intraperitoneal infection was 17.14%.Diabetes,MELD score,intraoperative bleeding and postoperative ascites were independent risk factors for intraperitoneal infection(P<0.05).Conclusion It is necessary to strengthen liver function maintenance,intraoperative bleeding control,reduce the third space effusion and blood sugar management of patients with diabetes to reduce intraperitoneal infection.