中性粒细胞/淋巴细胞比率与卵巢癌患者临床病理特征相关性的Meta分析

A Meta-analysis of the relationship between neutrophilto-lymphocyte ratio and clinicopathological characteristics of patients with ovarian cancer

目的探讨卵巢癌患者外周血中性粒细胞/淋巴细胞比率(NLR)与其临床病理特征的相关性。方法计算机检索PubMed、Embase、The Cochrane Library、Web of Science、中国知识基础设施工程、万方数据知识服务平台、中文科技期刊数据库、中国生物医学文献数据库共8个数据库,中文检索关键词为中性粒细胞/淋巴细胞比率、卵巢肿瘤及卵巢癌,英文检索词为NLR、neutrophils/lymphocytes、ovarian neoplasms及ovarian cancer,采用主题词与自由词相结合的方式进行检索,检索有关卵巢癌患者NLR与其临床病理特征并根据NLR截断值分为实验组(比值超过截断值)和对照组(比值低于截断值)的随机对照研究,检索时间从各数据库建库至2021年3月28日。通过筛选、提取数据和对纳入的研究进行质量评价后,采用Revman 5.3和Stata 15.1进行Meta分析。结果共纳入17项随机对照试验(RCT),共3820例卵巢癌患者。Meta分析结果显示,实验组卵巢癌肿瘤国际妇产科联盟(FIGO)分期处于晚期(Ⅲ/Ⅳ期)、糖类抗原125(CA125)高水平(CA125>500 U/ml)、腹水发生率均高于对照组,差异有统计学意义(P<0.05);但两组外周血NLR高低与卵巢癌组织学类型比较差异无统计学意义。结论高水平的NLR可作为卵巢癌患者部分临床病理特征不良的提示。

Objective To investigate the correlation between peripheral blood neutrophil/lymphocyte ratio(NLR)and its clinicopathological features in patients with ovarian cancer.Methods 8 databases including PubMed,Embase,The Cochrane Library,Web of Science,China Knowledge Infrastructure Project,Wanfang Data Knowledge Service Platform,Chinese Science and Technology periodical database and Chinese Biomedical Literature database were searched by computer.The Chinese keywords were neutrophil/lymphocytes ratio,ovarian tumors and ovarian cancer,and the English keywords were NLR,Neutrophils/lymphocytes,ovarian neoplasms and ovarian cancer.Using the combination of subject words and free words to search,randomized controlled studies on NLR and clinicopathological features of ovarian cancer patients were searched and divided into experimental group(ratio over cut-off value)and control group(ratio below cut-off value)according to NLR truncation value.The search time was from the inception of each database until March 28,2021.After screening,data extraction and quality evaluation of the included studies,meta-analysis was performed using Revman 5.3 and Stata 15.1.Results A total of 17 randomized controlled trials(RCTs)were included,with a total of 3820 patients with ovarian cancer.The results of Meta-analysis showed that Inter-national Federation of Gynecology and Obstetrics(FIGO)ovarian cancer in the experimental group was in advanced stage(Ⅲ/Ⅳ),carbohydrate antigen 125(CA125)was high(CA125>500 U/ml),and the incidence of ascites was higher than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference between NLR and histological type of ovarian cancer between the two groups.Conclusion High level of NLR can be used as an indication of some poor clinicopathological features in ovarian cancer patients.