百令胶囊治疗急性加重期慢性阻塞性肺病患者免疫细胞的影响

Effect of BaiLing capsule on immune cells in patients with acute exacerbation of chronic obstructive pulmonary disease

目的探讨百令胶囊对急性加重期慢性阻塞性肺病(AECOPD)患者免疫细胞的影响。方法选取2019年12月至2020年12月吉林市中心医院收治的110例AECOPD患者作为研究对象,随机分为实验组与对照组,每组55例。两组均给予常规治疗,实验组在常规治疗基础上予以百令胶囊口服治疗,对照组在常规治疗基础上口服淀粉胶囊治疗。比较治疗前后两组免疫相关指标(CD4^(+)、CD8^(+)、IgA、IgM、IgG)、肺功能指标[6 min步行试验(6 MWT)及第1秒呼气容积占用力肺活量比值(FEV_(1)/FVC)]。结果治疗1个月后,实验组CD4^(+)、IgA、IgM、IgG水平均高于治疗前,CD8^(+)水平低于治疗前,且实验组CD4^(+)、IgA、IgM、IgG水平均高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05)。治疗1个月后,实验组6 MWT、FEV_(1)/FVC均高于治疗前与对照组,差异有统计学意义(P<0.05)。结论百令胶囊治疗后可调节AECOPD患者免疫细胞数量,有助于改善患者的免疫功能,同时改善活动耐量及肺功能。

Objective To investigate the the effect of Baling capsule on the immune cells in patients with acute exacerbation chronic obstructive pulmonary disease(AECOPD).Methods A total of 110 patients with AECOPD admitted to Jilin City Central Hospital from December 2019 to December 2020 were selected as the study subjects,and they were randomly divided into the experimental group and the control group,with 55 cases in each group.The experimental group was treated with Bailing capsule on the basis of anti-inflammation,relieving spasm and resolving phlegm,while the control group was treated with starch capsule on the basis of relieving asthma,oxygen therapy.The immune indexes(CD4^(+),CD8^(+),IgA,IgM,IgG)and the lung function indexes(6-min walking test[6 MWT]and forced expiratory volume in one second/forced vita maximum l capacity[FEV_(1)/FVC])were compared between the two group before treatment and 1 month after treatment.Results After 1 month of treatment,the levels of CD4^(+),IgA,IgM and IgG in the experimental group were higher than before treatment,and the levels of CD8^(+)were lower than before treatment,and the levels of CD4^(+),IgA,IgM and IgG in the experimental group were higher than those in the control group,and the level of CD8^(+)was lower than that in the control group,the differences were statistically significant(P<0.05).After 1 month of treatment,6 MWT and FEV_(1)/FVC in the experimental group were higher than before treatment,and the control group,the differences were statistically significant(P<0.05).Conclusion Bailing capsule can regulate the number of immune cells in patients with AECOPD,improve the immune function,activity tolerance and lung function of patients with AECOPD.