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芪明颗粒联合康柏西普治疗糖尿病性黄斑水肿及对血管生长因子水平的影响

Qiming Granule Combined with Conbercept in the Treatment of Diabetic Macular Edema and Its Effect on the Level of Vascular Growth Factor
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摘要 目的研究探讨芪明颗粒联合康柏西普治疗糖尿病性黄斑水肿的临床疗效及对血管生长因子水平影响。方法选取2022年2月—2023年5月在牡丹江医学院附属红旗医院接受治疗的80例糖尿病性黄斑水肿患者为研究对象,按随机数表法分为对照组、观察组,各40例。对照组以康柏西普治疗,观察组增加芪明颗粒治疗。比较评估两组患者临床疗效、视力水平及黄斑水肿程度、血管内皮生长因子、氧化自由基水平、治疗安全性等。结果观察组总有效率为92.50%(37/40),高于对照组的75.00%(30/40),差异有统计学意义(χ^(2)=4.501,P=0.034)。治疗后,观察组最佳矫正视力高于对照组,黄斑区视网膜厚度、视网膜电图振荡电位均低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组血管内皮生长因子受体1、成纤维细胞生长因子受体、转化生长因子-β1水平均低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组丙二醛、8-羟化脱氧鸟苷水平均低于对照组,超氧化物歧化酶水平高于对照组,差异有统计学意义(P均<0.05)。观察组不良反应发生率为12.50%(5/40)、对照组的不良反应发生率为7.50%(3/40),两组比较,差异无统计学意义(P>0.05)。结论芪明颗粒联合康柏西普在糖尿病性黄斑水肿治疗中有良好应用效果,能改善视力水平,减少黄斑水肿厚度,抑制血管生长因子水平,改善机体的氧化应激反应能力,且治疗安全性良好。 Objective To investigate the clinical efficacy of Qiming Granule combined with Conbercept in the treatment of diabetic macular edema and its influence on the level of vascular growth factor.Methods A total of eighty patients with diabetic macular edema who received treatment in Hongqi Hospital Affiliated to Mudanjiang Medical College from February 2022 to May 2023 were selected as the objects and randomly divided into control group and observation group according to the random number table,with forty cases in each group.The control group was treated with Conbercept,and the observation group added Qiming Granule for treatment.The clinical efficacy,visual acuity level,degree of macular edema,vascular endothelial growth factor,oxidative free radical level and treatment safety of the two groups were compared and evaluated.Results The total effective rate of observation group was 92.50%(37/40),which was higher than that of control group 75.00%(30/40),and the difference was statistically significant(χ^(2)=4.501,P=0.034).After treatment,the best corrected visual acuity in the observation group was higher than that in the control group,and the retinal thickness and electroretinogram oscillating potential in macular area were lower than those in the control group,the differences were statistically significant(all P<0.05).After treatment,the levels of vascular endothelial growth factor receptor 1,fibroblast growth factor receptor and transforming growth factorβ1 in observation group were lower than those in control group,and the differences were statistically significant(all P<0.05).After treatment,the levels of malondialdehyde and 8-hydroxylated deoxyguanosine in observation group were lower than those in control group,and the levels of superoxide dismutase were higher than those in control group,the differences were statistically significant(all P<0.05).The incidence of adverse reactions was 12.50%(5/40)in the observation group and 7.50%(3/40)in the control group,and there was no statistically significant difference between the two groups(P>0.05).Conclusion Qiming Granule combined with Compaercep has a good application effect in the treatment of diabetic macular edema,which can improve the visual acuity level,reduce the thickness of macular edema,inhibit the level of vascular growth factor,improve the oxidative stress response ability of the body,and the treatment safety is good.
作者 帅天姣 张旭春 叶盛铭 丁颖昕 尹璐 李笑华 SHUAI Tianjiao;ZHANG Xuchun;YE Shengming;DING Yingxin;YIN Lu;LI Xiaohua(Department of Ophthalmology,Hongqi Hospital Affiliated to Mudanjiang Medical College,Mudanjiang,Heilongjiang Province,157011 China;The First Clinical Medical College of Mudanjiang Medical College,Mudanjiang,Heilongjiang Province,157011 China)
出处 《系统医学》 2024年第1期1-5,共5页 Systems Medicine
基金 黑龙江省省属高等学校基本科研业务费科研项目(2021-KYYWF-0509)。
关键词 糖尿病 黄斑水肿 康柏西普 芪明颗粒 临床疗效 血管生长因子 氧化应激反应 Diabetes mellitus Macular edema Conbercept Qiming Granule Clinical effect Vascular growth factor Oxidative stress reaction
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