普萘洛尔联合甲巯咪唑治疗甲亢患者的疗效及其对骨代谢指标水平的影响

Efficacy of Propranolol Combined with Methimazole in the Treatment of Hyperthyroidism Patients and Its Effect on the Levels of Bone Metabolism Indicators

目的分析对甲状腺功能亢进(简称甲亢)患者的治疗中应用普萘洛尔联合甲巯咪唑方案的临床效能及对患者代谢指标的改善效果。方法选取2020年1月—2022年12月伊犁哈萨克自治州友谊医院诊治的80例甲亢患者为研究对象,以数字排列法分为对照组和观察组,其中行甲巯咪唑治疗的40例患者为对照组,在对照组基础上联合普萘洛尔治疗的40例患者为观察组。评价两组患者的疗效、甲状腺功能、骨代谢水平及药物不良反应。结果观察组治疗有效率97.50%高于对照组的77.50%,差异有统计学意义(χ^(2)=7.314,P<0.05)。治疗后与对照组相比,观察组患者的血清游离甲状腺素(Free Thyroxine,FT4)、血清游离三碘甲状腺原氨酸(Free Triiodothyronine,FT3)、三碘甲状腺原氨酸(Triiodothyronine,T3)、甲状腺素(Thyroxine,T4)水平较低,促甲状腺素(Thyroid Stimulating Hormone,TSH)水平较高,差异有统计学意义(P均<0.05)。与对照组相比,观察组的骨代谢数据更为理想,差异有统计学意义(P<0.05)。两组患者的药物不良反应发生率相比,差异无统计学意义(P>0.05)。结论普萘洛尔与甲巯咪唑联合用于甲亢治疗中具有较佳效能,可促进患者的甲状腺激素与骨代谢表达恢复,且安全性较高,具有重要应用价值。

Objective To analyze the clinical efficacy of the application of propranolol combined with methimazole in the treatment of patients with hyperthyroidism and the improvement of metabolic indexes in patients.Methods 80 cases of hyperthyroidism treated at Ili Kazakh Autonomous Prefecture Friendship Hospital from January 2020 to December 2022 were selected as the research subjects.They were divided into a control group and an observation group using numerical arrangement method.Among them,40 patients treated with methimazole were selected as the control group,and 40 patients treated with propranolol in addition to the control group were selected as the observation group.The therapeutic efficacy,thyroid function,bone metabolism levels,and adverse drug reactions of the two groups were evaluated.Results The treatment effectiveness rate in the observation group was 96.00%higher than that in the control group(77.50%),and the difference was statistically significant(χ^(2)=7.314,P<0.05).After treatment,compared with the control group,the observation group had lower levels of serum free thyroxine(FT4),serum free triiodothyronine(FT3),triiodothyronine(T3),thyroxine(T4),and higher levels of thyroid stimulating hormone(TSH),and the differences were statistically significant(all P<0.05).Compared with the control group,the bone metabolism data of the observation group was more ideal,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse drug reactions between the two groups of patients(P>0.05).Conclu⁃sion The combination of propranolol and methimazole in the treatment of hyperthyroidism has better efficacy,which can promote the recovery of thyroid hormone and bone metabolism expression of the patients,and the safety is high,which has important application value.