氧化应激在脊髓损伤中的作用及机制研究进展

Research progress on the role and mechanism of oxidative stress in spinal cord injury

脊髓损伤(spinal cord injury,SCI)是严重影响中枢神经系统的疾病,其中氧化应激在SCI的继发性损伤中扮演关键角色。本文阐述了氧化应激在SCI中的作用、主要信号通路及现有治疗方法。重点关注Nrf-2、PI3K/AKT、TLR4/MyD88等通路在氧化应激调控中的作用,并探讨抗氧化疗法在减轻SCI症状中的潜力,旨在对深入理解SCI和优化治疗策略提供参考。

Spinal cord injury(SCI)is a disease that profoundly impacts the central nervous system,with oxidative stress playing a crucial role in its secondary damage.This article provides a comprehensive review of the role of oxidative stress in SCI,its primary signaling pathways,and current treatment methods.It focuses particularly on the functions of pathways such as Nrf-2,PI3K/AKT,and TLR4/MyD88 in the regulation of oxidative stress and explores the potential of antioxidant therapies in alleviating SCI symptoms.This paper aims to offer insights for a deeper understanding of SCI and provide reference for optimizing treatment strategies.