脂肪酸代谢紊乱与糖尿病血管微循环障碍

Fatty Acid Metabolism Disorders and Diabetic Vascular Microcirculation Dysfunction

脂肪酸过氧化物、脂质过氧化产物以及饱和脂肪酸是糖尿病脂肪酸代谢紊乱的特征性病理代谢产物,可通过诱导血小板聚集、引发血管收缩、增加血管通透性、诱发炎症反应等一系列机制,导致构成微循环结构的重要细胞发生功能障碍和损伤,诱发微循环障碍。现对上述机制及相关新型治疗策略做一综述,为其临床防治提供新的线索与思路。

Fatty acid peroxidation products,lipid peroxidation products,and saturated fatty acids are characteristic pathological metabolic products of fatty acid metabolic disorder in diabetes.They can induce platelet aggregation,trigger vasoconstriction,increased vascular permeability,and provoke inflammatory responses.These mechanisms lead to dysfunction and damage of vital cells that constitute the microcirculation,thus inducing microcirculatory disorders.This review discusses the above mechanisms and related novel therapeutic strategies,providing new clues and ideas for their clinical prevention and treatment.