扶正化瘀片联合多烯磷脂酰胆碱治疗慢性乙肝肝硬化患者的疗效

Influence of Fuzheng Huayu tablet combined with polyene phosphatidylcholine on liver function,liver fibrosis and serum indexes in patients with chronic hepatitis B cirrhosis

目的:探讨扶正化瘀片联合多烯磷脂酰胆碱治疗慢性乙肝肝硬化患者的疗效及其对肝功能、肝纤维化和血清指标的影响。方法:选取106例慢性乙肝肝硬化患者,按照治疗方式不同分为对照组和研究组,每组各53例。对照组给予常规治疗和多烯磷脂酰胆碱治疗;研究组在对照组基础上给予扶正化瘀片治疗,两组均治疗24周。比较两组患者的疗效、肝功能、肝纤维化指标、血清指标水平及不良反应发生情况。结果:研究组的临床总有效率为96.23%,高于对照组的83.02%(P<0.05)。治疗后,两组患者的总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、透明质酸酶(HA)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(IV-C)、层粘连蛋白(LN)、D二聚体(D-D)、总胆汁酸(TBA)水平均降低(P<0.05),且研究组均低于对照组(P<0.05);两组患者的白蛋白(ALB)、胆碱酯酶(CHE)水平均升高(P<0.05),且研究组高于对照组(P<0.05),两组不良反应总发生率无统计学差异(P>0.05)。结论:扶正化瘀片联合多烯磷脂酰胆碱治疗慢性乙肝肝硬化患者疗效显著,可有效改善患者肝功能,减轻肝纤维化,调节D-D、TBA及CHE的表达水平,并具有较好的安全性。

Objective:To investigate the influence of Fuzheng Huayu tablet combined with polyene phosphatidylcholine on liver function,liver fibrosis and serum indexes in patients with chronic hepatitis B cirrhosis.Methods:The 106 patients with chronic hepatitis B cirrhosis were choiced and splited into the control group and study group according to the different treament methods,with 53 cases in each group.The control group was treated with conventional therapy and polyene phosphatidylcholine,the study group was treated with Fuzheng Huayu tablet on the basis of the control group,and they were treated for 24 weeks.The clinical curative effect,liver function,liver fibrosis indexes,serum indexes levels and adverse reactions were compared between the two groups.Results:The total clinical effective rate of the study group was 96.23%,which was higher compared with 83.02%of the control group(P<0.05).Compared with before therapy,the total bilirubin(TBIL),alanine aminotransferase(ALT),aspartate aminotransferase(AST),hyaluronidase(HA),type III procollagen(PCⅢ),type IV collagen(IV-C),laminin(LN),D-dimer(D-D)and total bile acid(TBA)levels after therapy in the two groups were decreased(P<0.05),and the study group were lower compared with the control group(P<0.05).Compared with before therapy,the albumin(ALB)and cholinesterase(CHE)levels after therapy in both groups were increased(P<0.05),and the study group were higher compared with the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:The curative effect of Fuzheng Huayu tablet combined with polyene phosphatidylcholine in the therapy of patients with chronic hepatitis B cirrhosis is significant,which can effectively improve the liver function of patients,alleviate the liver fibrosis,regulate the expression levels of D-D,TBA and CHE,and with a good safety.