C反应蛋白联合血小板淋巴细胞比值预测动静脉内瘘失功的价值

C-reactive protein combined with platelet lymphocyte ratio to predicted the arteriovenous fistula dysfunction

目的:探讨C反应蛋白(CRP)联合血小板淋巴细胞比值(PLR)预测动静脉内瘘(AVF)失功的价值。方法:选取113例AVF功能障碍的患者为失功组;同期121例正常透析的患者为对照组。比较两组患者临床特征、淋巴细胞计数、PLR及CRP水平;Logistic回归分析影响AVF失功的危险因素;受试者工作特征(ROC)曲线分析CRP、PLR对AVF失功的预测效能。结果:两组患者年龄、是否合并糖尿病、淋巴细胞计数、PLR及CRP水平差异有统计学意义(P<0.05);回归分析结果显示,合并糖尿病、高CRP、高PLR是AVF失功的独立危险因素(P<0.05);ROC曲线分析显示,CRP、PLR、CRP+PLR预测AVF失功的曲线下面积(AUC)分别为0.623(95%CI:0.532~0.715)、0.629(95%CI:0.539~0.719)、0.703(95%CI:0.636~0.771)。结论:CRP、PLR升高是AVF失功的独立危险因素,均可用于预测AVF失功,两者联用时预测效能较高,具有一定预测价值。

Objective:To evaluate the clinical value of C-reactive protein(CRP)combined with platelet-lymphocyte ratio(PLR)in predicting arteriovenous fistula(AVF)dysfunction.Methods:113 patients with AVF dysfunction added to the treatment group,and in the same period 121 patients with maintenance hemodialysis dialysis were selected as the control group.The clinical characteristics,lymphocyte count,PLR,and CRP levels were compared between the two groups.The risk factors affecting AVF failure were analysed by Logistic regression,the predictive performance of CRP and PLR on AVF failure were analysed by Receiver Operating Characteristic(ROC)curve.Results:The age,diabetes,lymphocyte counts,PLR and CRP were found to be significant differences between the two groups(P<0.05).Binary Logistic regression analysis showed that diabetes,high CRP and high PLR were independent risk factors for loss of AVF patency(P<0.05).And ROC curve analysis showed that the area under the curve(AUC)of CRP,PLR and CRP+PLR in predicting AVF dysfunction was 0.623(95%CI:0.532~0.715),0.629(95%CI:0.539~0.719)and 0.703(95%CI:0.636~0.771).Conclusion:High CRP and high PLR are independent risk factors for AVF loss,either of the two can be used to predict the loss of AVF patency,and it is more accurate and has certain predictive value when used CRP combina PLR.