基于数据挖掘的中医药治疗颈性眩晕证治方药规律研究

Study on the Prescription Law of TCM for the Treatment of Cervical Vertigo Based on Data Mining

目的基于数据挖掘方法探讨中医药治疗颈性眩晕的证治方药规律。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)2013年1月1日-2023年1月1日中医药治疗颈性眩晕研究文献,运用WPS Office 11.1.0.14036软件统计方剂、疗法、证型、药物及药物性味归经的频次、频率;运用SPSS Statistics 25.0、SPSS Modeler 18.0软件对方药进行聚类分析和关联规则分析。结果纳入研究文献155篇,包含中医证型24种,方剂162首,中药119味。证型以痰湿中阻证、气血亏虚证为主,常用方剂类别为祛痰剂、补益剂,其中半夏白术天麻汤、益气聪明汤使用频次最高;常用药物类别为补虚药、解表药、活血化瘀药、平肝息风药、化痰药;药性以温性为主,药味以甘味为主,归经以脾经为主。聚类分析得出4个聚类方,关联规则分析得出11组药物组合。结论颈性眩晕主要证型为痰湿中阻证、气血亏虚证,治以化痰祛湿、益气升阳,方剂多选用半夏白术天麻汤、益气聪明汤;用药多性温味甘,以白术、半夏、天麻、葛根、茯苓为主。

Objective To discuss the prescription law of TCM for the treatment of cervical vertigo based on data mining.Methods Relevant literature on the TCM treatment for cervical vertigo was retrieved from databases of CNKI,Wanfang Data,and VIP from January 1,2013 to January 1,2023.After screening and inclusion,WPS Office 11.1.0.14036 software was used to calculate the frequency and distribution of prescriptions,combination therapy methods,syndrome types,drugs,and their properties,tastes,and meridians;the association rule analysis and clustering analysis were performed using SPSS Statistics 25.0 and SPSS Modeler 18.0 software.Results Totally 155 articles were included,involving 24 TCM syndrome types,162 prescriptions and 119 kinds of Chinese materia medica.Phlegm dampness obstruction syndrome and qi and blood deficiency deficiency syndrome were the main syndrome types.Commonly used formula categories are phlegm-expelling formula and supplementing formula.Banxia Baizhu Tianma Deccotion and Yiqi Congming Deccotion were the main prescriptions.Tonifying deficiency medicine,relieving exterior syndrome medicine,medicine of promoting blood circulation and resolving blood stasis,medicine of calming the liver and calming the wind,and medicine of resolving phlegm were the commonly used medicines;the statistics of property,taste and meridian showed that Chinese materia medica with the highest frequency was warm,sweet,and spleen meridian;clustering analysis could classify drugs into four categories;association rule analysis showed obtained 11 items of medicinal combinations.Conclusion The main syndrome types of cervical vertigo are phlegm dampness obstruction syndrome and qi and blood deficiency syndrome.Prescriptions with the efficacy of resolving phlegm,dispelling dampness,supplementing qi and elevating yang often include Banxia Baizhu Tianma Decoction and Yiqi Congming Decoction;the medication is mainly warm in property and sweet in the tastes,mainly with Atractylodis Macrocephalae Rhizoma,Jujubae Fructus,Gastrodiae Rhizoma,Puerariae Lobatae Radix and Poria.