基于数据挖掘的外治烧烫伤中药复方专利用药规律研究

Study on the Medication Law of National Patent Compounds of TCM for External Treatment of Burn and Scald

目的基于数据挖掘技术研究国家专利复方外治法治疗烧烫伤用药规律。方法检索国家知识产权局网站建库至2023年6月30日中医外治法治疗烧烫伤中药复方专利数据,运用Excel2019、SPSS Modeler 18.0、SPSS Statistics 25.0软件对纳入处方进行用药频次统计、性味归经统计、关联分析、聚类分析等。结果共纳入专利1147项,涉及处方1147首,药物1325味。使用频次>50的高频药物42味,药性以寒性为主,药味以苦、甘、辛味为主,药物归经以肝经、心经、肺经为主,药物类别以清热药、活血化瘀药、收敛止血药为主。药物二阶关联项集共10个,三阶关联项集共18个,黄连、黄芩、黄柏和大黄是药物关联项中的核心药物。高频药物聚类分为6类。结论国家专利复方外治烧烫伤以清热解毒、凉血止血、活血化瘀、消肿止痛等药物为主,临床可灵活化裁运用此类药物。

Objective To study the medication law of national patent compounds of TCM for external treatment of burn and scald based on data mining.Methods The website of the State Intellectual Property Office was searched for the data of external TCM compound patents for burn and scald,and Excel 2019,SPSS Modeler 18.0 and SPSS Statistics 25.0 were used to analyze the data on medication frequency,property and taste,meridian,association rules and clustering analysis of screened patent compounds.Results A total of 1147 patents were included in the study,involving 1147 prescriptions and 1325 kinds of Chinese materia medica.There were 42 kinds of high-frequency Chinese materia medica(frequency>50).The main property was cold,the main tastes were bitter,sweet and pungent,and meridians were mainly liver,heart and lung meridians.The maim medicinal categories were medicines of clearing-heat,promoting blood circulation and reducing stasis,and giving astringents to stop bleeding.10 secondorder correlation terms and 18 third-order correlation terms were obtained.Coptidis Rhizoma,Scutellariae Radi,Phellodendri Chinensis Cortex and Rhei Radix et Rhizoma were the key drugs in the drug association items.Clustering analysis of high-frequency drugs was divided into 6 categories.Conclusion The national patent compounds for external treatment of burn and scald are mainly composed of drugs such as clearing heat and detoxification,cooling blood and stopping bleeding,activating blood circulation and removing stasis and relieving swelling and pain,etc.Clinically,it can be flexibly applied according to such key drugs.