妊娠相关糖蛋白的生物学功能及其在畜牧生产中的研究进展

Research Progress on Biological Function and Application of Pregnancy Associated Glycoproteins in Livestock Production

妊娠相关糖蛋白(pregnancy associated glycoproteins, PAGs)属于天冬氨酸蛋白酶基因编码的多基因家族成员,由偶蹄类动物胎盘滋养层巨细胞合成分泌的特异性糖蛋白,可在胎盘附着后的母体循环中检测到。PAGs在胚胎附着、胎盘发育、妊娠维持、胚胎存活、蛋白水解活性和免疫调节等方面具有潜在作用,常作为早期妊娠诊断和胚胎丢失的生物标志物,同时还可作为检测胎儿生存能力和监测胎盘健康的指标。在本文主要综述了PAGs家族的起源及特征、生物学功能及其在畜牧生产上应用的研究进展,以期为深入探究PAGs的生物学功能以及推动其在畜牧业快速发展提供参考依据。

Pregnancy-associated glycoproteins(PAGs)belonging to the multigene family encoded by the aspartic protease gene,are a group of specific glycoproteins synthesized and secreted by placental trophoblast giant cells of artiodactyls,which can be detected in the maternal circulation after embryo attachment.It has the potential to serve multiple functions,including embryonic attachment,placental development,pregnancy maintenance,embryo survival,proteolytic activity,and immune regulation,which are most often used as biomarkers for early pregnancy diagnosis and assessment of embryo loss,as well as indicators of evaluation of fetal viability and monitoring placental health.In this paper,the origins and characteristics and biological functions of the PAGs family and its application in livestock production were reviewed,in order to provide reference for further research of PAGs biological functions and its rapid development in animal husbandry.