拉贝洛尔配合硝苯地平治疗妊娠期高血压的效果

Effect of labetalol combined with nifedipine in the treatment of pregnancy-induced hypertension

目的 观察在妊娠期高血压的治疗中实施拉贝洛尔配合硝苯地平治疗所取得的临床效果。方法 78例妊娠期高血压患者,随机分为对照组和观察组,各39例。对照组给予拉贝洛尔治疗,观察组给予拉贝洛尔联合硝苯地平治疗。比较两组新生儿不良结局、不良妊娠结局、药物不良反应发生情况、临床疗效以及治疗前后血液流变学(全血低切粘度、全血高切粘度、血浆粘度)、血压[收缩压(SBP)、舒张压(DBP)]、24 h尿蛋白定量。结果 观察组新生儿不良结局发生率7.69%低于对照组的25.64%(P<0.05)。观察组患者不良妊娠结局发生率10.26%低于对照组的28.21%(P<0.05)。治疗后,观察组患者SBP(120.56±6.65)mm Hg(1 mm Hg=0.133 kPa)、DBP(86.25±6.52)mm Hg、24 h尿蛋白定量(1.04±0.32)g/24 h低于对照组的(132.45±9.23)mm Hg、(98.45±7.12)mm Hg、(1.63±0.39)g/24 h(P<0.05)。观察组药物不良反应发生率5.13%低于对照组的23.08%(P<0.05)。观察组患者全血高切粘度(3.05±0.26)mPa·s、全血低切粘度(11.10±1.25)mPa·s、血浆粘度(1.32±0.12)mPa·s低于对照组的(4.99±0.44)、(14.87±2.05)、(1.88±0.21)mPa·s(P<0.05)。观察组患者生理功能评分(22.59±1.32)分、心理功能评分(23.65±2.64)分、躯体功能评分(22.46±1.45)分、社会功能评分(22.63±1.45)分均高于对照组的(17.56±1.41)、(18.45±3.52)、(15.96±1.52)、(17.52±1.36)分(P<0.05)。观察组患者治疗总有效率94.87%高于对照组的79.49%(P<0.05)。结论 在妊娠期高血压治疗中实施拉贝洛尔配合硝苯地平治疗效果突出,推荐应用于临床。

Objective To observe the clinical effect of labetalol combined with nifedipine in the treatment of pregnancy-induced hypertension.Methods 78 patients with pregnancy-induced hypertension were randomly divided into a control group and an observation group,with 39 cases in each group.The control group was treated with labetalol,and the observation group was treated with labetalol and nifedipine.Patients in both groups were compared in terms of neonatal adverse outcomes,adverse pregnancy outcomes,adverse drug reactions,clinical efficacy,hemorheology(whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity),blood pressure[systolic blood pressure(SBP),diastolic blood pressure(DBP)]and 24-h urinary protein quantity.Results The incidence of neonatal adverse outcomes in the observation group was 7.69%,which was lower than 25.64%in the control group(P<0.05).The incidence of adverse pregnancy outcomes in the observation group was 10.26%,which was lower than 28.21%in the control group(P<0.05).After treatment,the observation group had SBP of(120.56±6.65)mm Hg(1 mm Hg=0.133 kPa),DBP of(86.25±6.52)mm Hg,and 24-h urinary protein quantity of(1.04±0.32)g/24 h,which were lower than(132.45±9.23)mm Hg,(98.45±7.12)mm Hg,and(1.63±0.39)g/24 h in the control group(P<0.05).The incidence of adverse drug reactions of 5.13%in the observation group was lower than 23.08%in the control group(P<0.05).In the observation group,the whole blood high shear viscosity was(3.05±0.26)mPa·s,the whole blood low shear viscosity was(11.10±1.25)mPa·s and the plasma viscosity was(1.32±0.12)mPa·s,which were lower than(4.99±0.44),(14.87±2.05)and(1.88±0.21)mPa·s in the control group(P<0.05).In the observation group,the physiologic function score was(22.59±1.32)points,the psychological function score was(23.65±2.64)points,the physical function score was(22.46±1.45)points and the social function score was(22.63±1.45)points,which were higher than(17.56±1.41),(18.45±3.52),(15.96±1.52)and(17.52±1.36)points in the control group(P<0.05).The total effective rate of 94.87%in the observation group was higher than 79.49%in the control group(P<0.05).Conclusion The combination of labetalol and nifedipine is highly effective in the treatment of pregnancy induced hypertension and is recommended for clinical use.