肝炎肝硬化患者肝功能生化检验的临床应用价值观察

Observation on clinical application value of liver function biochemical test in patients with hepatitis cirrhosis

目的 探讨肝功能生化检验在肝炎肝硬化患者中的临床应用价值,以便为临床治疗提供参考。方法 选择72例肝炎肝硬化患者作为观察组, 50例健康体检者作为对照组。两组均开展肝功能生化检验。比较两组的肝功能生化指标[总胆汁酸(TBA)、白蛋白(ALB)、总胆固醇(TC)、胆碱酯酶(CHE)及胆固醇(CHO)],观察组不同Child-Pugh分级肝功能生化指标。结果 对照组TBA、ALB、CHE、CHO及TC水平分别为(6.25±0.72)μmol/L、(47.45±5.64)g/L、(5854.67±354.25)U/L、(4.11±0.74)mmol/L、(5.17±1.42)mmol/L,观察组分别为(39.78±5.16)μmol/L、(30.32±4.26)g/L、(2378.71±268.67)U/L、(2.93±0.51)mmol/L、(3.89±0.83)mmol/L,与对照组比较,观察组TBA水平升高, ALB、TC、CHE及CHO水平均降低,差异有统计学意义(P<0.05)。观察组不同Child-Pugh分级TBA、ALB、TC、CHE及CHO水平比较差异具有统计学意义(P<0.05)。Child A级患者TBA水平低于Child B级、Child C级, ALB、TC、CHE及CHO水平高于Child B级、Child C级, Child B级患者TBA水平低于Child C级, ALB、TC、CHE及CHO水平高于Child C级,差异具有统计学意义(P<0.05)。结论 肝炎肝硬化临床检测过程中使用肝功能生化检验,能有效对患者的肝功能状态进行评估,可判断其肝组织损伤程度,具有临床推广意义。

Objective To explore the clinical application value of liver function biochemical test in patients with hepatitis cirrhosis,so as to provide reference for clinical treatment.Methods A total of 72 patients with hepatitis cirrhosis were selected as the observation group and 50 healthy subjects were selected as the control group.Liver function biochemical test was performed in both groups.The biochemical indicators of liver function[total bile acid(TBA),albumin(ALB),total cholesterol(TC),cholinesterase(CHE)and cholesterol(CHO)]of the two groups were compared,as well as the biochemical indicators of liver function of patients with different Child-Pugh grades in the observation group.Results In the control group,the levels of TBA,ALB,CHE,CHO and TC were(6.25±0.72)μmol/L,(47.45±5.64)g/L,(5854.67±354.25)U/L,(4.11±0.74)mmol/L and(5.17±1.42)mmol/L.In the observation groups,those were(39.78±5.16)μmol/L,(30.32±4.26)g/L,(2378.71±268.67)U/L,(2.93±0.51)mmol/L and(3.89±0.83)mmol/L.Compared with the control group,TBA level in the observation group increased,and ALB,TC,CHE and CHO levels decreased.The difference was statistically significant(P<0.05).There were significant differences in TBA,ALB,TC,CHE and CHO levels among patients with different Child-Pugh grades in the observation group(P<0.05).TBA level of Child A patients was lower than that of Child B and Child C patients,and ALB,TC,CHE and CHO levels were higher than those of Child B and Child C patients;TBA level of Child B patients was lower than that of Child C patients,and ALB,TC,CHE and CHO levels were higher than those of Child C patients.The difference was statistically significant(P<0.05).Conclusion Liver function biochemical test in the clinical detection of hepatitis cirrhosis can effectively evaluate the liver function status of patients and judge the degree of liver tissue damage,which has clinical promotion significance.