临沂地区RhD阳性的无偿献血者表型分析

Phenotypic analysis of RhD positive unpaid blood donors in Linyi area

目的 研究临沂地区RhD阳性无偿献血人群Rh C、c、E、e抗原的分布规律。方法 采用血型血清学方法 ,利用全自动血型分析仪检测4563例RhD阳性无偿献血者的Rh血型C、c、E、e抗原表型分型。结果 在4563例RhD阳性无偿献血者中共检出9种表型,分别为CCee 1830例(40.11%),CcEe 1604例(35.15%), Ccee 460例(10.08%), ccEE 386例(8.46%), ccEe 215例(4.71%), ccee 23例(0.50%),CcEE 16例(0.35%), CCEe 28例(0.61%), CCEE 1例(0.02%)。经过对临沂地区4563例RhD阳性无偿献血者Rh C、c、E、e抗原统计分析发现, 4种抗原阳性所占百分比由高到低依次为e>C>c>E。结论 临沂地区RhD阳性无偿献血人群Rh分型以CCee和CcEe为主,最少见的是CCEE。对去白细胞悬浮红细胞合理选择表型为患者进行交叉配血,有助于减少Rh抗体的产生,尤其是有利于减少反复输血患者输血后产生Rh抗体的几率,同时有助于了解本地区无偿献血人群的Rh表型分布特点,对后期及时合理供血具有重要意义。

Objective To investigate the distribution of Rh blood group antigens C,c,E and e among RhD positive unpaid blood donors in Linyi area.Methods A total of 4563 RhD positive non-remunerative donors with Rh blood group C,c,E,e antigen phenotypes were detected by blood group serology using automatic blood group analyzer.Results A total of 9 phenotypes were detected in 4563 RhD positive unpaid blood donors,including 1830 cases(40.11%)of CCee,1604 cases(35.15%)of CcEe,460 cases(10.08%)of Ccee,and 386 cases(8.46%)of ccEE,215 cases(4.71%)of CcEe,23 cases(0.50%)of ccee,16 cases(0.35%)of CcEE,28 cases(0.61%)of CCEe,and 1 case(0.02%)of CCEE.The statistical analysis of Rh group antigens C,c,E and e of 4563 RhD positive unpaid blood donors in Linyi area showed that the positive percentage of 4 antigens was e>C>c>E from high to low.Conclusion The RhD positive unpaid blood donors in Linyi area are mainly classified by CCee and CcEe,and CCEE is the least common RH type.The selection of identical suspended red blood cells for cross matching is helpful to reduce the production of Rh antibodies.In particular,it is helpful to reduce the probability of Rh antibody production in patients with repeated blood transfusion.At the same time,it is helpful to understand the distribution characteristics of Rh phenotype among unpaid blood donors in this area,which is of great significance for timely and reasonable blood supply in the later period.