部分血液学参数预测急性心肌梗死PCI术后MACE价值的荟萃分析

Meta-analysis of the Value of Some Hematological Parameters in Predicting MACE After PCI in Acute Myocardial Infarction

目的运用Meta分析系统性的评价血小板计数(PLT)、血小板与淋巴细胞比值(PLR)、中性粒细胞与淋巴细胞比值(NLR)、平均血小板体积(MPV)预测急性心肌梗死患者PCI术后发生主要不良心血管事件(MACE)的价值。方法通过计算机检索PubMed、EMbase、CNKI、万方和维普数据库自建库至2022年3月1日公开发表的关于部分血液学参数预测PCI术后发生MACE的队列研究和病例对照研究,运用RevMan5.4.1软件进行Meta分析。结果共纳入33篇文献,总体样本量为11782例。Meta分析显示,高PLT(OR=48.03,95%CI:4.57~91.48)、高PLR(OR=3.18,95%CI:1.64~6.15)、高NLR(OR=2.06,95%CI:1.53~2.58)及高MPV(OR=0.84,95%CI:0.60~1.08)均易并发术后MACE,差异均有统计学意义(P<0.05)。结论PLT、PLR、NLR、MPV对急性心肌梗死患者PCI术后发生MACE具有一定的预测价值。

Objective To systematically evaluate the value of platelet count(PLT),platelet-to-lymphocyte ratio(PLR),neutrophil-to-lymphocyte ratio(NLR)and mean platelet volume(MPV)in predicting major adverse cardiovascular events(MACE)after PCI in patients with acute myocardial infarction by Meta-analysis.Methods PubMed,EMbase,CNKI,Wanfang and VIP databases were searched by computer for cohort studies and case-control studies on the prediction of MACE after PCI by some hematological parameters published from the establishment of the database to March 1,2022.Meta-analysis was performed using RevMan 5.4.1 software.Results A total of 33 articles were included,with an overall sample size of 11782 cases.Meta-analysis showed that high PLT(OR=48.03,95%CI:4.57-91.48),high PLR(OR=3.18,95%CI:1.64-6.15),high NLR(OR=2.06,95%CI:1.53-2.58)and high MPV(OR=0.84,95%CI:0.60-1.08)were prone to postoperative MACE,and the differences were statistically significant(P<0.05).Conclusion PLT,PLR,NLR and MPV have certain predictive value for MACE after PCI in patients with acute myocardial infarction.