2型糖尿病患者糖化血红蛋白变异指数与糖尿病肾病的关系

Relationship between Glycated Hemoglobin Glycation Index and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus

目的 分析2型糖尿病(Type 2 Diabetes, T2DM)患者糖化血红蛋白变异指数(Hemoglobin Glycation Index, HGI)与糖尿病肾病(Diabetic Nephropathy, DN)的关系。方法 选取2021年1月—2023年1月泉州市光前医院接诊的86例T2DM患者作为研究对象。根据患者入院时的HGI值,将其分成低HGI组(≤-0.85)、中HGI组(-0.85~0.55)、高HGI组(>0.55),分别为31、29、26例。检测3组患者的糖化血红蛋白(Glycosylated Hemoglobin A1c, HbA1c)水平,计算HGI;检测3组患者的空腹血糖(Fasting Blood Glucose, FBG)、总胆固醇(Total Cholesterol, TC)、三酰甘油(Triacylglycerol, TG)、低密度脂蛋白胆固醇(Low Density Lipoprotein Cholesterol, LDL-C)及高密度脂蛋白胆固醇(High-density Lipoprotein Cholesterol, HDL-C)水平、视黄醇结合蛋白(Retinol Binding Protein, RBP)、血肌酐(Creatinine, Scr)水平;使用Pearson进行相关分析。结果 3组患者的FBG、TC、TG、HDL-C水平比较,差异无统计学意义(P均>0.05);低HGI组、中HGI组、高HGI组患者的HbA1c、RBP、Scr、LDL-C水平对比,差异有统计学意义(P均<0.05)。Pearson相关分析发现,HGI分别与HbA1c、RBP、Scr、LDL-C值呈正相关(P均<0.05)。结论 HGI>0.55的T2DM患者更容易发生DN,并且HbA1c、RBP、LDL-C均影响DN发生及发展。

Objective To analyze the relationship between HGI and diabetic nephropathy(DN)in patients with type 2 diabetes(T2DM).Methods A total of 86 T2DM patients treated in Quanzhou Guangqian Hospital from January 2021 to January 2023 were selected as the study objects.According to the HGI value at admission,the patients were di-vided into low HGI group(≤-0.85),medium HGI group(-0.85-0.55)and high HGI group(>0.55),with 31 cases,29 cases and 26 cases,respectively.The level of glycosylated hemoglobin A1c(HbA1c)in the 3 groups was detected,and HGI was calculated.fasting blood glucose(FBG),total cholesterol(TC)and triacylglycerol were measured in 3 groups.TG,low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)level,retinol bind-ing protein(RBP)level,serum creatinine(Scr)level;Correlation analysis was performed using Pearson.Results There was no significant difference in the levels of FBG,TC and HDL-C among 3 groups(all P>0.05).The levels of HbA1c,RBP,Scr and LDL-C in low HGI group,medium HGI group and high HGI group were compared,and the differences were statistically significant(all P<0.05).Pearson correlation analysis showed that HGI was positively correlated with HbA1c,RBP,Scr and LDL-C,respectively(all P<0.05).Conclusion T2DM patients with HGI>0.55 were more likely to develop DN,and HbA1c,RBP and LDL-C all affected the development and progression of DN.