达格列净联合二甲双胍治疗对2型糖尿病患者血糖、胰岛敏感性的影响

Effect of Dapagliflozin Combined with Metformin Treatment on Blood Glucose and Islet Sensitivity in Type 2 Diabetes Mellitus Patients

目的 探讨达格列净联合二甲双胍治疗对2型糖尿病(Type 2 Diabetes Mellitus, T2MD)患者血糖、胰岛敏感性的影响。方法 选取2020年7月—2022年6月福建医科大学附属龙岩第一医院收治的70例T2MD患者,按随机数表法分为联用组(n=35)与单用组(n=35)。单用组给予二甲双胍,联用组给予达格列净联合二甲双胍,比较两组疗效。结果 治疗后,联用组空腹血糖、糖化血红蛋白餐后2 h血糖、胰岛素抵抗指数、丙二醛、终末氧化蛋白产物水平低于单用组,胰岛素分泌指数、胰岛素敏感性指数、总抗氧化能力、超氧化物歧化酶、过氧化氢酶水平高于单用组,差异有统计学意义(P均<0.05)。结论 达格列净联合二甲双胍治疗可有效调节T2MD患者糖代谢,增强胰岛敏感性,减轻胰岛素抵抗状况,控制血糖水平,明显改善机体氧化-抗氧化平衡。

Objective To investigate the effects of dapagliflozin combined with metformin treatment on blood glucose and islet sensitivity in patients with type 2 diabetes mellitus(T2MD).Methods 70 T2MD patients admitted to Long-yan First Hospital Affiliated to Fujian Medical University from July 2020 to June 2022 were selected and divided into the combination group(n=35)and the monotherapy group(n=35)by random number table method.Metformin was given to the monotherapy group and dapagliflozin combined with metformin was given to the combination group to com-pare the efficacy of the two groups.Results After treatment,the levels of glucose,glycasylated hemoglobin,2-hour plasma glucose,homeostatic model assessment-insulin resistance,malondialdehyde,and advanced oxidation protein product were lower in the combination group than those in the monotherapy group,and the levels of homeostasis model assessment-insulin sensitivity,homeostasis model assessment-β,total-antoxidant capability,superoxide dis-mutase,and catalase were higher than those in the monotherapy group,and the differences were statistically signifi-cant(all P<0.05).Conclusion Dapagliflozin combined with metformin treatment can effectively regulate glucose me-tabolism in T2MD patients,enhance islet sensitivity,reduce insulin resistance status,control blood glucose levels,and significantly improve the oxidation-antioxidant balance of the body.