司美格鲁肽在2型糖尿病患者中的心血管保护作用研究

Study on the Cardioprotective Effects of Semaglutide in Patients with Type 2 Diabetes Mellitus

目的 探究司美格鲁肽在2型糖尿病(Type 2 Diabetes, T2DM)患者中的心血管保护作用。方法 选取2023年1—10月广东省佛山市顺德明景糖尿病医院接受治疗的90例T2DM患者作为研究对象,根据随机数表法分为对照组和观察组,每组45例,对照组采用二甲双胍治疗,观察组采用二甲双胍联合司美格鲁肽治疗。对比不同治疗方式的应用疗效。结果 治疗后,观察组血糖指标低于对照组,差异有统计学意义(P<0.05);治疗后,观察组总胆固醇(3.81±0.85)mmol/L、低密度脂蛋白胆固醇(2.47±0.19)mmol/L低于对照组,差异有统计学意义(t=2.693、2.991,P均<0.05);治疗后,观察组炎性因子水平低于对照组,差异有统计学意义(P<0.05)。结论 T2DM患者治疗中,在二甲双胍基础上加入司美格鲁肽,可稳定血糖及血脂情况,优化血清炎性因子水平,具有心血管保护作用。

Objective To investigate the cardioprotective effect of semaglutide in patients with type 2 diabetes melli-tus(T2DM).Methods A total of 90 patients with T2DM who received treatment in Shunde District Mingjing Diabetes Hospital from January to October 2023 were selected as the study objects,and divided into control group and observa-tion group according to random number table method,with 45 cases in each group.The control group was treated with metformin.Observation group was treated with metformin combined with semaglutide.The therapeutic effects of differ-ent treatment methods were contrasted.Results After treatment,the blood glucose index of observation group was lower than that of control group,the difference was statistically significant(P<0.05).After treatment,total cholesterol(3.81±0.85)mmol/L and low density lipoprotein cholesterol(2.47±0.19)mmol/L in observation group were lower than those in control group,the differences were statistically significant(t=2.693,2.991,both P<0.05).After treatment,the level of inflammatory factors in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of T2DM patients,the addition of simethicone to metfor-min can stabilize the blood glucose and lipid profile,optimize the serum inflammatory factor level,and have cardiovas-cular protective effects.